Elevated Plasma Platelet Activating Factor, Platelet Activating Factor Acetylhydrolase Levels and Risk of Coronary Heart
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Elevated Plasma Platelet Activating Factor, Platelet Activating Factor Acetylhydrolase Levels and Risk of Coronary Heart Disease or Blood Stasis Syndrome of Coronary Heart Disease in Chinese: A Case Control Study Guo-Hua Zheng,1,3 Shang-Quan Xiong,2 Li-Juan Mei,1 Hai-Ying Chen,1 Ting Wang,2 and Jian-Feng Chu1
Abstract—The purpose of the study was to explore the association between plasma platelet activating factor (PAF) and platelet activating factor acetylhydrolase (PAF-AH) levels and risk of coronary heart disease (CHD) or blood stasis syndrome (BSS) of CHD. Questionnaire, routine clinical assays and plasma levels of PAF, PAF-AH and inflammatory factors hs-CRP and IL-6 were investigated or measured for 120 controls and 150 CHD patients (66 non-BSS and 84 BSS). Plasma PAF levels were higher in CHD patients [49.7 (34.8–73.2 pg/mL)] than in controls [23.8 (14.9– 42.3 pg/mL)] (P 50 %); and age between 35 and 80 years. Excluded were patients who were in any of the following conditions: severe infection; severe heart failure (ejection fraction1 cigarette each day were defined as current smokers. Those who stopped smoking>1 year previously were considered as past smokers, and the remaining were defined as nonsmokers. The clinical assay markers mainly including
BLOOD SPECIMEN COLLECTION AND LABORATORY METHODS
STATISTICAL ANALYSIS Data were collected and analyzed using SPSS13.0 software (SPSS Inc., Chicago, USA). All probability values are derived from two-tailed analysis, and those below 0.05 have been considered to be of statistical significance. Categorical data were analyzed by using χ2 test or Fisher’s exact test as appropriate. Continuous variables are expressed as mean and standard deviation (SD) or medians and interquartile ranges, and are analyzed with two-tailed t test for normal distributions and the Mann–Whitney U test for non-normal distributions. To account for the case–control study,
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Zheng, Xiong, Mei, Chen, Wang, and Chu
single or multiple variable logistic regression analysis was performed to estimate the odds ratio (OR) of CHD or BSS associated with each risk factor. Plasma PAF, PAF-AH, IL6 and hs-CRP level exhibits a lognormal distribution, and data were therefore transformed before logistic regression analysis and Pearson correlation analysis. The transformed data of PAF, PAF-AH, IL-6 and hs-CRP were divided into dichotomization based on their medians. Pearson correlation analysis was used to evaluate the correlation among the levels of plasma PAF, PAF-AH, hs-CRP and IL6. The associations between plasma PAF-AH and PAF levels and the risk of CHD or BSS were evaluated by using binary logistic regression model.
RESULTS The Baseline Characteristics of Study Population The baseline characteristics of the study population are displayed in Table 1. As expected, age, body mass index (BMI), smoking, family history of hypertension and CHD were found to be significantly higher in CHD patients than in controls. Current blood pressure including systolic and diastolic pressure was not significant between CHD ca
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