Embryology and PGD

The success of any PGD programme relies on there being a successful embryology laboratory for assisted conception. In addition to routine skills required as part of IVF for infertility, there are additional procedures that need to learned in order to proc

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Preimplantation Genetic Diagnosis in Clinical Practice

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Preimplantation Genetic Diagnosis in Clinical Practice

Tarek El-Toukhy • Peter Braude Editors

Preimplantation Genetic Diagnosis in Clinical Practice

Editors Tarek El-Toukhy Assisted Conception Unit and PGD Centre Guy’s and St. Thomas’ Hospital NHS Foundation Trust Guy’s Hospital London UK

Peter Braude Division of Women’s Health King’s College London St. Thomas’ Hospital London UK

ISBN 978-1-4471-2947-9 ISBN 978-1-4471-2948-6 DOI 10.1007/978-1-4471-2948-6 Springer London Heidelberg New York Dordrecht

(eBook)

Library of Congress Control Number: 2013953723 © Springer-Verlag London 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

This book is dedicated to Ali and Ishrak and to Professor Sir Robert G. Edwards (1925-2013), scientist, mentor and friend, whose tenacity and foresight brought joy to so many through IVF and PGD.

Contents

1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Peter Braude and Tarek El-Toukhy

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2 Basic Genetics for PGD . . . . . . . . . . . . . . . . . . . . . . . . Frances Flinter and Fiona Stewart

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3 Genetic Counselling and Its Role in PGD. . . . . . . . . Alison Lashwood

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4 Complex Issues in PGD . . . . . . . . . . . . . . . .