Emerging relationship between RNA helicases and autophagy
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Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.jzus.zju.edu.cn; www.springerlink.com E-mail: [email protected]
Review:
Emerging relationship between RNA helicases and autophagy* Miao-miao ZHAO1,2, Ru-sha WANG1,2, Yan-lin ZHOU3, Zheng-gang YANG†‡1,2 1
The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
2 3
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China
Department of Gastroenterology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China †
E-mail: [email protected]
Received May 10, 2020; Revision accepted Aug. 10, 2020; Crosschecked Sept. 7, 2020
Abstract: RNA helicases, the largest family of proteins that participate in RNA metabolism, stabilize the intracellular environment through various processes, such as translation and pre-RNA splicing. These proteins are also involved in some diseases, such as cancers and viral diseases. Autophagy, a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival, is associated with human diseases. Interestingly, similar to autophagy, RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases. According to recent studies, RNA helicases are closely related to autophagy, participate in regulating autophagy, or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progression of diseases. Here, we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases. Key words: RNA helicase; Autophagy; Homeostasis; Regulation https://doi.org/10.1631/jzus.B2000245 CLC number: R34
1 Introduction Autophagy is a highly evolutionarily conserved physiological process that represents a cellular degradation pathway. Currently, autophagy is divided into three types: chaperone-mediated autophagy, microautophagy, and macroautophagy. Macroautophagy (hereafter referred to as autophagy) has been widely studied and much is currently known about this process. Autophagy is mainly supported by transient double-membrane vesicles called autophagosomes. ‡
Corresponding author Project supported by the State S&T Project of 13th Five Year of China (No. 2018ZX10302206), the National Basic Research Program (973) of China (No. 2017YFA0503402), and the Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Hangzhou, China ORCID: Zheng-gang YANG, https://orcid.org/0000-0001-9014-2245 © Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature 2020 *
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