Empagliflozin
- PDF / 169,891 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 44 Downloads / 182 Views
1 S
Empagliflozin Euglycaemic diabetic ketoacidosis: case report
A 51-year-old man developed euglycaemic diabetic ketoacidosis during treatment with empagliflozin for type II diabetes mellitus. The man, who had a history of type II diabetes mellitus with poor glycaemic control, had been receiving treatment with empagliflozin [route and dosage not stated]. He presented to the hospital with nausea, asthenia, general malaise, hyporexia and decreased level of consciousness [duration of treatment to reaction onset not stated]. Subsequently, he was hospitalised. On admission, he was noted as dehydrated and poorly perfused. He exhibited shallow breathing, and was tachypnoeic and tachycardic. Biochemistry tests showed glucose level of 185 mg/dL, urea 164 mg/dL, creatinine 1.62 mg/dL, ketone bodies 6.2 mmol/L and PCT 6.15 ng/mL with the ions and normal liver function tests. Haemogram showed haemoglobin level of 11.9 g/dL, leucocyte count of 14000 and platelet count of 195000. The blood gas analysis showed severe metabolic acidosis with a pH of 7.08, base excess of 26200 and bicarbonate level of 5.3. Thus, he was diagnosed with euglycaemic diabetic ketoacidosis. The man was treated with intensive fluid therapy and bicarbonate. He also required orotracheal intubation, sedation and analgesia. He was mechanically ventilated and renal replacement was started with continuous veno-venous haemodiafilteration. Additionally, infusion of insulin was started. Subsequently, the acid-base parameters and the level of glucose normalised. After 24h, he was extubated, and was discharged home on the fourth day after withdrawal of insulin infusion and normalisation of ketone bodies. Gonzalez-Castro A, et al. Euglycemic diabetic ketoacidosis. Medicina Clinica 152: 416-417, No. 10, 17 May 2019. Available from: URL: http://doi.org/10.1016/ j.medcli.2018.05.029 [Spanish; summarised from a translation]
0114-9954/20/1819-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
803498654
Reactions 29 Aug 2020 No. 1819
Data Loading...
