Endometrial Gene Expression An Emerging Paradigm for Reproductive Di
The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus an
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Endometrial Gene Expression
Joanne Kwak-Kim Editor
Endometrial Gene Expression An Emerging Paradigm for Reproductive Disorders
Editor Joanne Kwak-Kim Reproductive Medicine and Immunology Clinical Sciences, Obstetrics and Gynecology, Microbiology and Immunology Chicago Medical School, Rosalind Franklin University of Medicine and Science Vernon Hills, IL USA
ISBN 978-3-030-28583-8 ISBN 978-3-030-28584-5 (eBook) https://doi.org/10.1007/978-3-030-28584-5 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Endometrial Gene Expression: An Emerging Paradigm for Reproductive Disorders is a book devoted to endometrial gene expressions. This book is the first to focus on endometrial gene expression and gynecological pathologies in terms of reproduction, endometriosis, and other gynecological diseases. A recent development in molecular genetic technology opens a new era of endometrial assessment for various gynecological conditions, including infertility. Endometrium goes through structural changes cyclically under the hormonal influence to accommodate the implantation of an embryo. When implantation does not happen, menstruation occurs. Immune effectors in the endometrium dynamically change their populations during the menstrual cycle and set up immune responses with appropriate cytokine and chemokine milieus. The number of uterine natural killer (uNK) cells increases significantly during the luteal phase and reaches 70% of decidual lymphocytes in early pregnancy. Natural killer (NK) cell trafficking from the peripheral blood to the endometrium, as well as the proliferation of uterine NK cells, contributes to the rapid accumulation of NK cell
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