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Various toxicities: 4 case reports In a retrospective cohort study, involving 142 patients with traumatic intracranial haemorrhage and who received prothrombin complex concentrate from 2005 to 2015, 1 woman and 3 men aged 60–80 years were described, who developed mesenterial ischemia, pulmonary embolism, myocardial infarction, cardioembolic cerebral ischemic lesions, subdural haematoma, traumatic subarachnoid haemorrhage, traumatic intracerebral haemorrhage or subdural haematoma progression during treatment with heparin, enoxaparin-sodium, phenprocoumon or unspecified prothrombin complex concentrate [dosages, routes, durations of treatments to reactions onsets and outcomes not stated]. Patient 1: A 70-year-old woman had a significant history of coronary heart disease, atrial fibrillation, arterial hypertension and heart valve replacement. She had been receiving anticoagulant therapy with phenprocoumon. Following her presentation to the hospital, a subsequent CT scan showed subdural haematoma. She was hospitalised and started receiving unspecified prothrombin complex concentrate for anticoagulation reversal. She also received enoxaparin-sodium [Clexane] anticoagulation therapy in addition to compression stockings. Following the treatment, she exhibited acute abdomen. After 5 days of prothrombin complex concentrate administration, based on exploratory laparotomy results, she was diagnosed with mesenterial ischaemia. Therefore, she underwent craniotomy and haematoma evacuation. However, after 5 days of her admission, she died [aetiology not stated]. Patient 2: An 80-year-old man had a significant history of atrial fibrillation and arterial hypertension. He had been receiving anticoagulant therapy with phenprocoumon. Following his presentation to the hospital, a subsequent CT scan showed subdural haematoma, traumatic intracerebral haemorrhage, traumatic subarachnoid haemorrhage and fracture. He was hospitalised and started receiving unspecified prothrombin complex concentrate for anticoagulation reversal. He also received enoxaparin-sodium [Clexane] anticoagulation therapy in addition to compression stockings. Following the treatment, he exhibited dyspnoea. After 3 days of prothrombin complex concentrate administration, based on elevated D-dimers and CT pulmonary angiography results, he was diagnosed with pulmonary embolism. Therefore, he started receiving treatment with heparin. However, he exhibited subdural hematoma progression during the treatment. Therefore, he underwent carinotomy. After 6 months of his admission, he died [aetiology not stated]. Patient 3: A 74-year-old man had a significant history of atrial fibrillation, coronary heart disease and diabetes mellitus. He had been receiving anticoagulant therapy with phenprocoumon. Following his presentation to the hospital, a subsequent CT scan showed fracture and subdural haematoma. He was hospitalised and started receiving unspecified prothrombin complex concentrate for anticoagulation reversal. He also received enoxaparin-sodium [Clexane] anticoagulation