Epidemiology of an Underdiagnosed Syndrome
The first description of Klinefelter syndrome (KS) dates back to 1942, when Harry F. Klinefelter et al. (J Clin Endocrinol 2(11):615–627, 1942) reported the occurrence of a ‘not uncommon’ syndrome characterized by small testes, tall stature, gynaecomastia
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ndrea Garolla Giovanni Corona Editors
Klinefelter’s Syndrome From a Disabling Condition to a Variant of Normalcy
Trends in Andrology and Sexual Medicine Series Editors Andrea Lenzi Chair of Endocrinology, Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology Sapienza University of Rome Roma, Italy Carlo Foresta Chair of Endocrinology, Department of Medicine, Unit of Andrology and Reproductive Medicine University of Padova Padova, Italy Emmanuele A. Jannini Chair of Endocrinology & Medical Sexology (ENDOSEX), Department of Systems Medicine University of Rome Tor Vergata Roma, Italy Mario Maggi Chair of Endocrinology, Department of Experimental, Clinical and Biomedical Sciences, Andrology and Sexual Medicine Unit University of Florence Florence, Italy
This series will serve as a comprehensive and authoritative resource that presents state of the art knowledge and practice within the fields of Andrology and Sexual Medicine, covering basic science and clinical and psychological aspects. Each volume will focus on a specific topic relating to reproductive or sexual health, such as male and female sexual disorders (from erectile dysfunction to vaginismus, and from hypoactive desire to ejaculatory disturbances), diagnostic issues in infertility and sexual dysfunction, and current and emerging therapies (from assisted reproduction techniques to testosterone supplementation, and from PDE5i to SSRIs for premature ejaculation). In addition, selected new topics not previously covered in a single monograph will be addressed, examples including male osteoporosis and the approach of traditional Chinese medicine to sexual medicine. Against the background of rapid progress in Andrology and Sexual Medicine, the series will meet the need of readers for detailed updates on new discoveries in physiology and pathophysiology and in the therapy of human sexual and reproductive disorders. More information about this series at http://www.springer.com/series/13846
Andrea Garolla • Giovanni Corona Editors
Klinefelter’s Syndrome From a Disabling Condition to a Variant of Normalcy
Editors Andrea Garolla Unit of Andrology and Reproductive Medicine University of Padua Padua Italy
Giovanni Corona Endocrinology Unit Ospedale Maggiore Bologna Italy
ISSN 2367-0088 ISSN 2367-0096 (electronic) Trends in Andrology and Sexual Medicine ISBN 978-3-030-51409-9 ISBN 978-3-030-51410-5 (eBook) https://doi.org/10.1007/978-3-030-51410-5 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks,
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