Epithelial-Mesenchymal Interactions in Cancer
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Epithelial-Mesenchymal Interactions in Cancer Edited by I.D. Goldberg E.M. Rosen
Birkhauser Verlag Basel . Boston . Berlin
Editors
Dr. I.D. Goldberg Dr. E.M. Rosen Long Island Jewish Medical Center Institute of Oncology New Hyde Park N.Y. 11042 USA
Library of Congress Cataloging-in-Publication Data Epithelial-mesenchymal interactions in cancer I edited by I.D.
Goldberg, E.M. Rosen. p. cm. - (Exs; 74) Includes bibliographical references and index.
1. Epithelium-Tumors. 2. Mesenchyme-Pathophysiology. 3. Cancer invasiveness. 4. Carcinogenesis. 5. Fibroblasts. 6. Transforming growth factors. I. Goldberg, I.D. (ltzhak David), 1948II. Rosen, E.M. (Eliot M.) III. Series: Experientia. Supplementum; v. 74. [DNLM: 1. Epithelium-physiology. 2. Mesoderm-physiology. 3. Stromal Cells-physiology. 4. Cell Transformation, Neoplastic. 5. Neoplasm Metastasis. 6. Neoplasm Invasiveness. EX23 v. 74 1995 I QZ 365 E64 1995] RC280.E66E65 1995 616.99'4071-dc20 DNLM/DLC for Library of Congress
Deutsche Bibliothek Cataloging-in-Publication Data
EXS. - Basel; Boston; Berlin: Birkhauser. Friiher Schriftenreihe Fortlaufende Bei!. zu: Experientia 74. Epithelial-mesenchymal interactions in cancer. - 1995 Epithelial-mesenchymal interactions in cancer I ed. by I.D. Goldberg; E.M. Rosen. - Basel; Boston; Berlin: Birkhauser, 1995 (EXS; 74) NE: Goldberg, Itzak D. [Hrsg.] The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use registered names, trademarks etc. in this publication, even if noot identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use permission of the copyright owner must be obtained. © 1995 Birkhauser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Softcover reprint of the hardcover 1st edition 1995 Printed on acid-free paper produced from chlorine-free pulp. TCF 00 ISBN-13: 978-3-0348-9893-5 DOl: 10.1007/978-3-0348-9070-0 987654321
e-ISBN-13: 978-3-0348-9070-0
Dedicated to the memory of Gertrude Kurz, whose character, devotion and courage were an inspiration to all who knew her. Itzhak D. Goldberg
Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
IX
W. Birchmeier and C. Birchmeier Epithelial-mesenchymal transitions in development and tumor progresSIon. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
E.M. Rosen and I.D. Goldberg Regulation of scatter factor (hepatocyte growth factor) production by tumor-stroma interaction. . . . . . . . . .
