Erythrocyte membrane fatty acid profile and saturation index in gallbladder carcinogenesis: a case-control study
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Erythrocyte membrane fatty acid profile and saturation index in gallbladder carcinogenesis: a case-control study Manoj Pandey*1, Lal B Sharma2, Shailesh Singh3 and Vijay K Shukla2 Address: 1Department of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, 695 011, Kerala, India, 2Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India and 3Current address Department of Microbiology & Immunology, Morehouse School of Medicine, 720 Westview Drive, SW Atlanta, GA 30310, USA Email: Manoj Pandey* - [email protected]; Lal B Sharma - [email protected]; Shailesh Singh - [email protected]; Vijay K Shukla - [email protected] * Corresponding author
Published: 7 May 2003 World Journal of Surgical Oncology 2003, 1:5
Received: 12 February 2003 Accepted: 7 May 2003
This article is available from: http://www.wjso.com/content/1/1/5 © 2003 Pandey et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
gallbladdercarcinogenesisfatty desaturase acidstearic acidoleic acidarachidonic acidlipid peroxidationgallstoneslipid bilayersignal transductiondelta 9
Abstract Background: Gallbladder cancer is a common neoplasm of biliary tract, with an unknown etiology. Patients and methods: This study was carried out to evaluate the changes in the membrane fatty acid profile and saturation index in patients with gallbladder cancer. The study sample consisted of 50 newly diagnosed cases of gallbladder cancer and 50 patients undergoing cholecystectomy for cholelithiasis were recruited as controls. The fatty acid estimation was carried out by high performance liquid chromatography (HPLC). Statistical analysis was carried out by student 't' test and one-way ANOVA. Pearson's correlation coefficient was also obtained. Results: A significant lowering of erythrocyte membrane stearic acid (p = 0.000), arachidonic acid (p = 0.001), and saturation index (p = 0.001) was observed in patients with gallbladder cancer compared to controls. A significant inverse relation was observed between stearic and oleic acid (r = -0.269 p = 0.007). Conclusion: Results of the present study suggest an increase in the delta 9 desaturation in cancer patients compared to controls however, a possible role of biliary stasis due to altered gallbladder motility or derangements of signal transduction secondary to altered membrane lipid bilayer cannot be ruled out.
Introduction Fatty acids are long chain organic acids and form a major component of membrane lipids. A membrane fatty acid profile is thought to reflect the body composition as well as dietary fat intake [1]. Of these, polyunsaturated fatty acids (PUFA) are prone to free radical attack and hydrogen abstraction, the oxidative damage being termed as lipid
peroxidation [2]. This causes a reduction in the membrane fluidity and permeabili
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