Estimating the incidence of lung cancer attributable to occupational exposure in Iran
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BioMed Central
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Estimating the incidence of lung cancer attributable to occupational exposure in Iran Alireza Mosavi-Jarrahi*1,2, Mohammadali Mohagheghi2, Bita Kalaghchi2, Yasaman Mousavi-Jarrahi3 and Mohammad Kazem Noori4 Address: 1Dept of Public Health and Social Medicine, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran, 2The Cancer Institute Research Center, Tehran University, Tehran, Iran, 3Dept of Health Economic, Medical School, Shahed University, Tehran, Iran and 4Environmental health and safety office, The Bureau of Development and Renovation organization of Mine and Mineral industries, Tehran, Iran Email: Alireza Mosavi-Jarrahi* - [email protected]; Mohammadali Mohagheghi - [email protected]; Bita Kalaghchi - [email protected]; Yasaman Mousavi-Jarrahi - [email protected]; Mohammad Kazem Noori - [email protected] * Corresponding author
Published: 12 May 2009 Population Health Metrics 2009, 7:7
doi:10.1186/1478-7954-7-7
Received: 18 May 2008 Accepted: 12 May 2009
This article is available from: http://www.pophealthmetrics.com/content/7/1/7 © 2009 Mosavi-Jarrahi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Objective: The aim of this study was to estimate the fraction of lung cancer incidence in Iran attributed to occupational exposures to the well-established lung cancer carcinogens, including silica, cadmium, nickel, arsenic, chromium, diesel fumes, beryllium, and asbestos. Methods: Nationwide exposure to each of the mentioned carcinogens was estimated using workforce data from the Iranian population census of 1995, available from the International Labor Organization (ILO) website. The prevalence of exposure to carcinogens in each industry was estimated using exposure data from the CAREX (CARcinogen EXposure) database, an international occupational carcinogen information system kept and maintained by the European Union. The magnitude of the relative risk of lung cancer for each carcinogen was estimated from local and international literature. Using the Levin modified population attributable risk (incidence) fraction, lung cancer incidence (as estimated by the Tehran Population-Based Cancer Registry) attributable to workplace exposure to carcinogens was estimated. Results: The total workforce in Iran according to the 1995 census identified 12,488,020 men and 677,469 women. Agriculture is the largest sector with 25% of the male and 0.27% of female workforce. After applying the CAREX exposure estimate to each sector, the proportion exposed to lung carcinogens was 0.08% for male workers and 0.02% for female workers. Estimating a relative risk of 1.9 (95% CI of 1.7–2.1) for high exposure and 1.3 (95% CI 1.2–1.4) for low exposure, and employing the Levin modified fo
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