Estimation of radiation exposure of children undergoing superselective intra-arterial chemotherapy for retinoblastoma tr
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INTERVENTIONAL NEURORADIOLOGY
Estimation of radiation exposure of children undergoing superselective intra-arterial chemotherapy for retinoblastoma treatment: assessment of local diagnostic reference levels as a function of age, sex, and interventional success Marcel Opitz 1 & Denise Bos 1 & Cornelius Deuschl 1 & Alexander Radbruch 1 & Sebastian Zensen 1 & Selma Sirin 1 & Michael Forsting 1 & Nikolaos Bechrakis 2 & Eva Biewald 2 & Norbert Bornfeld 2 & Petra Ketteler 3 & Beate Timmermann 4 & Martin Stuschke 5 & Maja Guberina 5 & Axel Wetter 1 & Sophia Göricke 1 & Nika Guberina 1,5 Received: 22 May 2020 / Accepted: 23 August 2020 # The Author(s) 2020
Abstract Purpose This study aims to determine local diagnostic reference levels (LDRLs) of intra-arterial chemotherapy (IAC) procedures of pediatric patients with retinoblastoma (RB) to provide data for establishing diagnostic reference levels (DRLs) in pediatric interventional radiology (IR). Methods In a retrospective study design, LDRLs and achievable dose (AD) were assessed for children undergoing superselective IAC for RB treatment. All procedures were performed at the flat-panel angiography systems (I) ArtisQ biplane (Siemens Healthineers) and (II) Allura Xper (Philips Healthcare). Patients were differentiated according to age (A1: 1–3 months; A2: 4–12 months; A3: 13–72 months; A4: 73 months–10 years; A5: > 10 years), sex, conducted or not-conducted chemotherapy. Results 248 neurointerventional procedures of 130 pediatric patients (median age 14.5 months, range 5–127 months) with RB (68 unilateral, 62 bilateral) could be included between January 2010 and March 2020. The following diagnostic reference values, AD, and mean values could be determined: (A2) DRL 3.9 Gy cm2, AD 2.9 Gy cm2, mean 3.5 Gy cm2; (A3) DRL 7.0 Gy cm2, AD 4.3 Gy cm2, mean 6.0 Gy cm2; (A4) DRL 14.5 Gy cm2, AD 10.7 Gy cm2, mean 10.8 Gy cm2; (A5) AD 8.8 Gy cm2, mean 8.8 Gy cm2. Kruskal-Wallis-test confirmed a significant dose difference between the examined age groups (A2–A5) (p < 0.001). There was no statistical difference considering sex (p = 0.076) and conducted or not-conducted chemotherapy (p = 0.627). A successful procedure was achieved in 207/248 cases. Conclusion We report on radiation exposure during superselective IAC of a pediatric cohort at the German Retinoblastoma Referral Centre. Although an IAC formally represents a therapeutic procedure, our results confirm that radiation exposure lies within the exposure of a diagnostic interventional procedure. DRLs for superselective IAC are substantially lower compared with DRLs of more complex endovascular interventions. Keywords Radiation exposure . Retinoblastoma . Intra-arterial chemotherapy . Interventional neuroradiology
* Marcel Opitz [email protected] 1
2
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany Department of Ophthalmology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
3
Department of Pediatric Hematolo
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