• PDF / 169,767 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 29 Downloads / 140 Views

DOWNLOAD

REPORT

---

1 S

Various toxicities: case report A 25-year-old woman developed chronic spontaneous urticaria during treatment with ethinylestradiol/levonorgestrel. Additionally, she experienced drowsiness, tired feeling and fatigue during treatment with cetirizine for chronic spontaneous urticaria [routes not stated; not all durations of treatments to reactions onset and outcomes stated]. The woman, who had a history of bronchial asthma and allergic rhinitis, started receiving ethinylestradiol/levonorgestrel 0.02mg/0.100mg film-coated tablets as a contraceptive from January 2016. However, she developed urticaria from August 2016 probably triggered by ethinylestradiol/levonorgestrel. She experienced severe confluent urticaria, which worsened with pressure, sunlight, water and contact. A very poor quality of life was observed. She reported experiencing about 70% of her body surface covered with urticaria on certain days. The woman was treated with cetirizine 10 mg/day, which was increased till 40 mg/day. However, she had not achieve complete resolution. She developed side effects in the form of drowsiness, fatigue and tired feeling associated with cetirizine. The treatment with ethinylestradiol/levonorgestrel was discontinued in September 2018, and she was treated with omalizumab. Her symptoms resolved and chronic urticaria quality of life questionnaire (CU-Q2oL) and urticaria activity score (UAS) scores totally improved. She had no exacerbations during this period and in the last 3 months without omalizumab. Cozzi L. Chronic urticaria (CU) and levonorgestrel/ethinylestradiol therapy: is there a link?. World Allergy Organization Journal 13: 63-64 abstr. P110, No. 8, Aug 2020. 803514969 Available from: URL: http://doi.org/10.1016/j.waojou.2020.100225 [abstract]

0114-9954/20/1830-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 14 Nov 2020 No. 1830