Ethnic differences in normal retinal capillary density and foveal avascular zone measurements
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ORIGINAL PAPER
Ethnic differences in normal retinal capillary density and foveal avascular zone measurements Audrey Giocanti-Aure´gan . Gaspard Gazeau . Linda Hrarat . Vincent Le´vy . Fatima Amari . Bahram Bodaghi . Franck Fajnkuchen
Received: 24 January 2020 / Accepted: 20 June 2020 Ó Springer Nature B.V. 2020
Abstract Background The purpose of this study was to quantify retinal capillary density and foveal avascular zone (FAZ) area in healthy subjects according to their ethnicity, using optical coherence tomography angiography (OCTA). Methods In this cross-sectional study, all eyes underwent swept-source OCTA (Triton, Topcon, Tokyo, Japan). Macular OCTA scans (3 9 3 mm) were obtained in healthy white Caucasian and black African subjects. The FAZ area and capillary density in both the superficial (SCP) and deep capillary plexuses (DCP) were automatically measured using
Meeting presentation: presented as a paper at the international OCT angiography meeting in Roma, December 2017. A. Giocanti-Aure´gan (&) L. Hrarat F. Amari B. Bodaghi F. Fajnkuchen Ophthalmology Department, Avicenne Hospital, 125 rue de Stalingrad, 93000 Bobigny, France e-mail: [email protected] G. Gazeau V. Le´vy Clinical Research Department, Avicenne Hospital, 125 rue de Stalingrad, Bobigny, France B. Bodaghi Ophthalmology Department, Pitie´ Salpe´trie`re Hospital, 91 boulevard de l’hoˆpital, Paris, France F. Fajnkuchen Centre d’imagerie et de Laser, 11 rue Antoine Bourdelle, Paris, France
a custom-made software combining vessel binarization and skeletonization. Results Twelve eyes of 12 healthy Caucasians and 15 eyes of 15 healthy black Africans were included in the analysis. The mean FAZ area was significantly smaller, and the overall vessel density (VD) was higher in the SCP and DCP of Caucasians compared to black Africans. The mean FAZ area was 0.26 ± 0.008 mm2 in the SCP and 0.25 ± 0.05 mm2 in the DCP in Caucasians versus 0.33 ± 0.08 mm2 in the SCP (p = 0.01) and 0.37 ± 0.1 mm2 in the DCP (p = 0.03) in Africans. In the SCP and DCP, the mean VD was, respectively, 40.5 ± 0.8% and 47.1 ± 0.5% in Caucasians versus 34.3 ± 1% (p = 0.008) and 40.6 ± 0.9% in Africans (p \ 0.001). Discussion/conclusion In the SCP and DCP, VD is lower in black Africans compared to Caucasians. In OCTA studies on vascular diseases, ethnicity-matched measurements from healthy subjects should be used for comparisons. Keywords OCT angiography Foveal avascular zone Vascular density Ethnicity Abbreviations DCP Deep capillary plexus FAZ Foveal avascular zone ICP Intermediate capillary plexus OCTA Optical coherence tomography angiography SCP Superficial capillary plexus
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Int Ophthalmol
VD
Vessel density
Background Optical coherence tomography angiography (OCTA) is a noninvasive tool that allows visualizing the superficial (SCP), intermediate (ICP) and deep (DCP) capillary retinal plexuses [1–3] without injection of fluorescein. An increasing number of studies have used OCTA to assess all types of
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