Etiopathogenesis
In 1991, a small annual meeting named "International Winter Conference on Neurodegeneration (lWCN)" was established; the aim of this meeting is to review the neurodegenerative disorders and to attempt to explore how progress might be made in this field, a
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Advances in Research on Neurodegeneration Series Editorial Advisory Board D.B. CaIne The University of British Columbia Vancouver, Canada R. Horowski Schering AG Berlin Berlin, Germany Y oshikuni Mizuno Juntendo University Tokyo, Japan Werner H. Poewe Universitatsklinikum Rudolf Virchow Berlin, Germany P. Riederer University of Wiirzburg Wiirzburg, Germany Ingeborg Runge Schering AG Berlin Berlin, Germany M.B.H. Y oudim Israel Institute of Technology Haifa, Israel
Advances in Research on Neurodegeneration, Volume II Etiopathogenesis
Y. Mizuno D. B. CaIne R. Horowski Editors
Birkhauser Boston • Basel • Berlin
Yoshikuni Mizuno Department of Neurology Juntendo University School of Medicine Hongo, Bunkyo, Tokyo 113 Japan
R. Horowski Schering AG Berlin Clinical Research Special Research Projects MiHlerstraBe 170-178 D-IOOO Berlin 65 Germany
Donald B. Caine The University of British Columbia Director, Neurodegenerative Disorders Center Purdy Pavillion The Vancouver Hospital, Health Sciences Center 2211 Wesbrook Mall Vancouver, B.C. Canada V6T IW5 Printed on acid-free paper. ©1994 Birkhiiuser Boston
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Softcover reprint ofthe hardcover lst edition 1994
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ISBN 978-1-4684-9203-3 (eBook)
DOl 10.1007/978-1-4684-9203-3
Typeset by Alden Multimedia, Northampton, England.
Contents Preface . . . . . . . . . . . . . Y. Mizuno, D.B. Caine, R. Horowski
IX
List of Contributors
Xl
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PART I: GENETIC, GROWTH, AND ENVIRONMENTAL FACTORS Genetic Evidence for a Novel Familial Alzheimer's Disease Locus on Chromosome 14: Analysis of Candidate Genes P.H. St George-Hyslop. .
