Evaluating Health Related Quality of Life in Older People at Risk of Osteoporotic Fracture: A Head-to-Head Comparison of
- PDF / 845,304 Bytes
- 16 Pages / 439.37 x 666.142 pts Page_size
- 31 Downloads / 171 Views
Evaluating Health Related Quality of Life in Older People at Risk of Osteoporotic Fracture: A Head‑to‑Head Comparison of the EQ‑5D‑5L and AQoL‑6D Lei Si1,2 · Liudan Tu3 · Ya Xie3 · Gang Chen4 · Mickaël Hiligsmann5 · Mingcan Yang3 · Yanli Zhang3 · Xi Zhang3 · Yutong Jiang3 · Qiujing Wei3 · Jieruo Gu3 · Andrew J. Palmer6,7 Accepted: 15 June 2020 © Springer Nature B.V. 2020
Abstract We aimed to conduct a head-to-head comparison of the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L) and the Assessment of Quality of Life-6D (AQoL-6D) in measuring health-related quality of life (HRQoL) of older people at risk of osteoporotic fracture. Participants (n = 291) were recruited from the Third Affiliated Hospital of Sun Yat-Sen University. Study participants were asked to complete the EQ5D-5L and the AQoL-6D and the results were converted to health-state utilities (HSUs) using population-specific scoring algorithms. The agreement among HSUs was evaluated using the intraclass correlation coefficient and illustrated using Bland–Altman plots. The minimally important difference (MID) for the EQ-5D and AQoL was set at 0.074 and 0.06. Information on socio-demographic background, socio-economic status and clinical risk factors in F RAX® was collected. Nonparametric statistics were used to explore the knowngroup validity measured by fracture risk. Mean (median) EQ-5D-5L and AQoL-6D HSUs were 0.73(0.83) and 0.74(0.79) for the study population. The EQ-5D-5L and the AQoL-6D HSUs strongly agreed and the HSU difference reached the MID level in both instruments. While a decreasing trend of AQoL-6D utilities was observed with worsening bone mineral density, EQ-5D-5L HSUs were similar in individuals with normal and osteopenic bone mineral densities. The AQoL-6D was also effective for measuring difference in independent living, relationships, mental health, coping and pain. Both instruments showed good known-group validity. The EQ-5D-5L and AQoL-6D are all valid measures for older people at risk of osteoporotic fracture. Keywords Health-related quality-of-life · EQ-5D · Assessment of quality of life · Chinese · Osteoporosis
Lei Si and Liudan Tu contributed equally. * Jieruo Gu [email protected] Extended author information available on the last page of the article
13
Vol.:(0123456789)
L. Si et al.
1 Introduction Osteoporosis is a systemic skeleton disorder characterized by low bone density and structural deterioration of bone tissue with an increased risk of fracture (Osteoporosis prevention, diagnosis, and therapy 2001). The prevalence of osteoporosis has risen in the past decade and now affects more than 30% of Chinese aged 50 years and older (Chen et al. 2016a, b). Osteoporosis has become a major health issue and incurs tremendous economic and disease burdens on Chinese society (Si et al. 2015). More importantly, patients with osteoporosis suffer decreased physical function, social function and well-being and increased pain. These health aspects are often addressed and measured by health-related qualit
Data Loading...
