Evaluation of antimicrobial properties of a novel synthesized nanometric delafossite
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BACTERIAL AND FUNGAL PATHOGENESIS - RESEARCH PAPER
Evaluation of antimicrobial properties of a novel synthesized nanometric delafossite Mohsen A. Sayed 1 & Asmaa A. H. El-Bassuony 2
&
H. K. Abdelsalam 3
Received: 24 April 2020 / Accepted: 13 August 2020 # Sociedade Brasileira de Microbiologia 2020
Abstract Antibiotics and other antimicrobial compounds are the backbone of clinical medicine. Antimicrobial resistance can cause serious diseases to man. Nanotechnology can improve therapeutic potential of medicinal molecules and related agents. Widespread application of antibiotics and other antimicrobial compounds led to development of multidrug-resistant microbes, so there is need to develop novel therapeutic agents. Novel synthesized nanometric delafossite was assayed against two Gram-positive bacteria (Staphylococcus aureus and Micrococcus luteus), two Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae), four opportunistic fungi (Aspergillus flavus, A. fumigatus, A. niger, and Fusarium solani), and four Candida species (C. albicans, C. parapsilosis, C. krusei, and C. tropicalis) using diffusion assay method. The minimum inhibitory concentration (MIC) of the novel synthesized nanometric delafossite was determined using the dilution method. The assayed compounds showed different degrees of antifungal and antibacterial activities, depending on the annealing temperature of preparation of these compounds. Compounds prepared at room temperature showed greater antimicrobial activities than those prepared at higher temperatures. The antimicrobial activity depends also on the susceptibility of the test microbe. Keywords Novel nanometric delafossite . Antimicrobial activity . Minimum inhibitory concentration (MIC) . Resistant species . Opportunistic microorganisms
Introduction Resistant bacteria and fungi are unaffected by antimicrobial compounds [1]. In bacteria, the widespread use of antibiotics, especially beta-lactams, may select resistant strains harboring the NDM-1 (New Delhi metallo-beta-lactamase 1) gene, which confers resistance to a broad range of beta-lactams [2, 3]. In fungi, resistance to fluconazole has been reported. Such resistance includes alteration or increase in the drug target, Responsible Editor: Fernando R. Pavan * Asmaa A. H. El-Bassuony [email protected]; [email protected]; http:// scholar.cu.edu.eg/?q=phys/ 1
Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt
2
Physics Department, Faculty of Science, Cairo University, Giza, Egypt
3
Basic Science Department, Higher Institute of Applied Arts 5th Settlement, New Cairo, Egypt
increased drug efflux, and development of compensatory pathways for production of the target sterol [4]. Moreover, resistance to fluconazole has particular importance in non-Candida albicans spp. due to the increased infections by these fungal sp. worldwide and the elevated resistance to commonly used azole [5]. However, mycotic diseases caused by Candida albicans have increased greatly in the last two decades. The sp
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