Evidence Based Pathology and Laboratory Medicine
Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in th
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Alberto M. Marchevsky • Mark R. Wick Editors
Evidence Based Pathology and Laboratory Medicine
Editors Alberto M. Marchevsky, MD Director, Pulmonary and Mediastinal Pathology Department of Pathology and Laboratory Medicine Cedars-Sinai Medical Center and Clinical Professor of Pathology David Geffen School of Medicine University of California Los Angeles, CA, USA [email protected]
Mark R. Wick, MD Professor and Associate Director of Surgical Pathology Department of Pathology University of Virginia Medical School Charlottesville, VA, USA [email protected]
ISBN 978-1-4419-1029-5 e-ISBN 978-1-4419-1030-1 DOI 10.1007/978-1-4419-1030-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011925569 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Pathology and laboratory medicine are currently experiencing paradigm shifts that are likely to influence how our specialty is practiced in the not-toodistant future. Technical innovations in immunohistochemistry, molecular pathology, and pathology informatics are driving the acquisition of many new and exciting data. That phenomenon may well increase the quality and scope of the diagnostic information being provided by laboratory assays. Simultaneously, however, as new technologies invariably increase the cost of medical testing, considerable pressure has accrued concerning financial containment. Thus far, advocates of “the most, the newest, and the best, regardless of cost” have largely prevailed. Nonetheless, it is likely that in the near future, there will be considerable movement toward a strict, cost-effective utilization of laboratory resources that is centered on clinical value and direct applicability of test results in regard to individual patient care. As practicing pathologists, it has been our impression that there is a great interest in the generation
