Excitation-Contraction Coupling and Cardiac Contractile Force
How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking abou
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Excitation-Contraction Coupling and Cardiac Contractile Force Second Edition by
DONALD M. BERS Professor and Chair Department of Physiology, Loyola University Chicago, Maywood, IL, U.S.A.
SPRINGER-SCIENCE+BUSINESS MEDIA, B.V.
A C.I.P. Catalogue record for this book is available from the Library of Congress.
ISBN 978-0-7923-7158-8 ISBN 978-94-010-0658-3 (eBook) DOI 10.1007/978-94-010-0658-3
Printed an acid-tree paper
AII Rights Reserved © 2001 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 2001 Softcover reprint of the hardcover 2nd edition 2001 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, includ ing photocopying, record ing or by any information storage and retrieval system, withoutwritten permission from the copyright owner.
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PREFACE TO FIRST EDITION The main aim of this monograph is to provide an overview of calcium regulation in cardiac muscle cells, particularly with respect to excitation-contraction coupling and the control of cardiac contractile force. It is my hope that this book will be useful to students of the cardiovascular system and muscle at all different levels and in different disciplines (such as physiology, biochemistry, pharmacology and pathophysiology). I also hope that it will find use for those studying developmental, comparative and disease processes as well as more integrative phenomenon. I kept several goals in mind in writing this monograph. First, it should be easily readable. Second, I chose to include numerous illustrations and tables to help integrate results from numerous investigators in practical formats and also present key figures from important papers. Thus, this monograph may serve as a resource of information for people working in the areas described herein. Third, the presentation is a very personal one, and I have necessarily drawn extensively on my personal experience in this field over the past 15 years. This, I think, helps maintain a certain continuity of thought from chapter to chapter. Fourth, I have made serious attempts to make each chapter "up to date", despite the breadth of topics covered. I have also tried to be equitable in choosing references while not intending to be comprehensive or exhaustive. Neither of these aims can be perfectly matched, and I apologize to the many investigators whose papers I have not cited, but should have. While I thank all of my colleagues who make this a stimulating area in which to work, I would especially like to thank those who contributed by helpful discussions, providing original figures, sending preprints of manuscripts, and by commenting on drafts of individual chapters. These individuals include: S. Baudet, B.P. Bean, J.R. Berlin, J.H.B. Bridge, A. Fabiato, S. Fleischer, J.S. Frank, C. Franzini-Armstrong, M.M. Hosey, L.V. Hryshko, N. Ikemoto, L.R. Jones, W.J. Lederer, D.H. MacLennan, G. Meissner, M. Morad, K.D. Philipson, J.D. Potter, E. Rios, R.J. Solaro, J.R. Sommer
