Exercise interventions improve depression and anxiety in chronic kidney disease patients: a systematic review and meta-a

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NEPHROLOGY - REVIEW

Exercise interventions improve depression and anxiety in chronic kidney disease patients: a systematic review and meta‑analysis Thalita Lauanna Ferreira1   · Heitor Siqueira Ribeiro1,2   · Alexandre Lima Araújo Ribeiro2   · Ana Clara Bonini‑Rocha3   · Joana Marcela Sales Lucena3   · Poliana Alves de Oliveira3   · Francisco Rafael S. Amorim3   · Aparecido Pimentel Ferreira1   · Luiz Alexandre Viana Magno4   · Wagner Rodrigues Martins2,3  Received: 13 June 2020 / Accepted: 12 August 2020 © Springer Nature B.V. 2020

Abstract Purpose  This systematic review examined the effects of exercise interventions on depression and anxiety in chronic kidney disease patients. Methods  Electronic searches were conducted between August 2019 and February 2020 at PubMed, MEDLINE, Web of Science, EBSCO, Scopus, LILACS, EMBASE, Physiotherapy Evidence Database, and Cochrane Library databases. Original clinical trial studies that examined the effects of exercise on depression and anxiety in chronic kidney disease patients, stages 3–5, were included. A total of eight studies were included in the systematic review after applying the eligibility criteria, and six studies used for the meta-analysis procedures. Results  The meta-analysis demonstrated statistical difference on depression in favour to exercise when compared to active control (SMD = − 0.66 [− 1.00, − 0.33], p