Expanding the host range: infection of a reptilian host ( Furcifer pardalis ) by an atypical Brucella strain
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Expanding the host range: infection of a reptilian host (Furcifer pardalis) by an atypical Brucella strain Tobias Eisenberg . Karen Schlez . Ahmad Fawzy . Iris Vo¨lker . Silke Hechinger . Mersiha Curic´ . Nicole Schauerte . Christina Geiger . Jochen Blom . Holger C. Scholz
Received: 12 May 2020 / Accepted: 8 July 2020 Ó The Author(s) 2020
Abstract Atypical brucellae show deviant phenotypes and/or genotypes. Besides Brucella inopinata, B. microti and B. vulpis, atypical strains have been described infecting humans, rodents, amphibians and fish. They represent potential zoonotic agents. Here, we provide evidence that reptiles as the remaining poikilothermic vertebrate class also represent susceptible hosts for atypical Brucella.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10482-020-01448-9) contains supplementary material, which is available to authorized users. T. Eisenberg (&) K. Schlez A. Fawzy I. Vo¨lker S. Hechinger M. Curic´ Department of Veterinary Medicine, Hessian State Laboratory (LHL), Schubertstr. 60/ Haus 13, 35392 Giessen, Germany e-mail: [email protected] A. Fawzy Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza Square, Giza 12211, Egypt
Keywords Brucella Chameleon Reptile Coldblooded animal Poikilothermic Whole genome sequencing Devriesea agamarum
Introduction The medically important genus Brucella comprises a historical clade of six so called classical Brucella species (the type species Brucella melitensis and B. abortus, B. canis, B. ovis, B. neotomae and B. suis) plus some recently described species including B. pinnipedialis, B. ceti, B. microti, B. inopinata, B. J. Blom Bioinformatics and Systems Biology, Justus-LiebigUniversity Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany H. C. Scholz Department of Bacteriology and Toxinology, Bundeswehr Institute of Microbiology, Neuherbergstrasse 11, 80937 Munich, Germany
N. Schauerte C. Geiger Frankfurt Zoo, Bernhard-Grzimek-Allee 1, 60316 Frankfurt, Germany
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Antonie van Leeuwenhoek
papionis and B. vulpis (Foster et al. 2007; Scholz et al. 2008, 2010, 2016b; Whatmore et al. 2014). A number of further atypical strains have been isolated in the past decade from humans, wildlife mammals, amphibians and fish (Eisenberg et al. 2012, 2017; Tiller et al. 2010a, b). Despite striking whole genome similarities of these monomorphic pathogens of above 99% atypical brucellae commonly carry additional genetic material not found in classical Brucella species but present in soil associated bacteria of the Alphaproteobacteria (Al Dahouk et al. 2017). Most of the accessory genes with known function encode additional metabolic proteins, ABC transporters or represent bacteriophages and mobile genetic elements that indicate a different ecology in comparison to the classical host-adapted Brucella species (Scholz et al. 2016a). To date, no such atypical
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