Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma
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RESEARCH
Open Access
Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma Hui Zhang1*†, Hongli Gao2†, Chengli Liu1, Yalin Kong1, Cheng Wang1 and Hongyi Zhang1
Abstract Background: It has been shown that heat shock-related 70-kDa protein 2 (HSPA2), a member of the HSP70 family of heat shock proteins, is important for cancer cell growth and metastasis. However, the status of HSPA2 expression and its prognostic significance in pancreatic cancer remain unknown. Methods: Quantitative reverse transcriptase ploymerase chain reaction (qRT-PCR) was applied to examine HSPA2 messenger RNA (mRNA) expression in 104 pairs of pancreatic cancer tissues and adjacent noncancerous tissues. Statistical analyses were applied to evaluate the diagnostic value and associations of HSPA2 expression with clinicopathological characteristics. Results: HSPA2 mRNA was significantly overexpressed in pancreatic cancer tissues (3.9 ± 0.8) than in adjacent normal tissues (1.1 ± 0.4) (P < 0.001). Clinicopathological analysis showed that HSPA2 expression was significantly correlated with tumor size (P = 0.024), histological differentiation (P = 0.012), TNM stage (P = 0.006), lymph node metastasis (P = 0.043) and serum CA19-9 level (P = 0.046). Moreover, patients with higher HSPA2 expression levels had shorter overall survival time than those with lower HSPA2 expression levels (P = 0.019). Furthermore, Cox regression analyses showed that HSPA2 expression was an independent predictor of overall survival (P = 0.011). Conclusions: Our results suggest that overexpression of HSPA2 in pancreatic cancer is associated with aggressive progression and poor prognosis and that HSPA2 may be served as a prognostic marker. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/5988744821527257. Keywords: HSPA2, Pancreatic cancer, Overall survival, Prognosis
Background Pancreatic cancer remains to be one of the most challenging malignancies to treat. Surgical resection offers the only opportunity for cure. However, as no valid method for early detection of this disease has been established, 80% or more of patients present with unresectable disease at the time of diagnosis [1]. Furthermore, even when resection is performed, the recurrence rate is extremely high, resulting in the 5-year survival rate of patients with resected pancreatic cancer being no more than 20% [2]. Currently, carbohydrate antigen 19–9 (CA19-9) is commonly used for pancreatic cancer detection. However, the sensitivity and specificity of CA19-9 * Correspondence: [email protected] † Equal contributors 1 Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, Beijing 100142, China Full list of author information is available at the end of the article
for the early diagnosis of pancreatic cancer are low [3]. Therefore, more accurate and acceptable tumor markers for the early detection of pancreatic cancer are needed. Heat shock-related 70-kDa protein 2 (HSPA2, also known as HSP70-2) is
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