Extended application of subtraction arterial phase imaging in LI-RADS version 2018: a strategy to improve the diagnostic
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HEPATOBILIARY-PANCREAS
Extended application of subtraction arterial phase imaging in LI-RADS version 2018: a strategy to improve the diagnostic performance for hepatocellular carcinoma on gadoxetate disodium–enhanced MRI Seung-seob Kim 1 & Sunyoung Lee 1 Myeong-Jin Kim 1
&
Heejin Bae 1 & Yong Eun Chung 1 & Jin-Young Choi 1 & Mi-Suk Park 1 &
Received: 4 May 2020 / Revised: 13 July 2020 / Accepted: 26 August 2020 # European Society of Radiology 2020
Abstract Objectives This study aimed to assess the detection of hepatocellular carcinoma (HCC) utilizing subtraction AP (arterial phase) imaging only for T1 hyperintense observations compared with the detection of HCC on subtraction AP imaging that included T1 hyper-, iso-, and hypointense lesions on gadoxetate disodium–enhanced MRI. Materials and methods This retrospective study included 234 patients (311 observations including 239 HCCs) at high risk for HCC who underwent gadoxetate disodium–enhanced MRI with subtraction AP imaging between 2015 and 2017. Arterial phase hyperenhancement (APHE) was divided into two subtypes: conventional APHE, where subtraction AP imaging is used to detect APHE only for T1 hyperintense observations; and modified APHE, where subtraction AP imaging is applied to T1 hyper-, iso-, and hypointense lesions. Two readers independently reviewed all observations and the per-observation diagnostic performances were compared using McNemar’s test. Results Modified nonrim APHE showed significantly higher sensitivity than conventional nonrim APHE (90.0% vs 82.8%; p < 0.001) for diagnosing HCC, without a significant difference in specificity (66.7% vs 68.1%; p > 0.999). The LR-5 category with modified nonrim APHE provided better sensitivity than the LR-5 with conventional nonrim APHE (70.3% vs 63.2%; p < 0.001), without a significant decrease in specificity (94.4% vs 95.8%; p > 0.999). Conclusion Extended application of subtraction AP imaging for T1 hypo- or isointense observations on gadoxetate disodium– enhanced MRI can improve sensitivity in the diagnosis of HCC without a significant difference in specificity. Key Points • Modified nonrim arterial phase hyperenhancement (APHE), extended application of subtraction arterial phase imaging for T1 hypo- or isointense observation, outperforms conventional nonrim APHE. • The LR-5 category with modified nonrim APHE provided better sensitivity in diagnosing HCC than the LR-5 with conventional APHE, without a significant decrease in specificity. Keywords Liver neoplasms . Diagnosis . Sensitivity and specificity . Magnetic resonance imaging . Subtraction technique Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-07229-2) contains supplementary material, which is available to authorized users. * Sunyoung Lee [email protected] 1
Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea
Abbreviations AP Arterial phase APHE
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