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Various toxicities: 10 case reports In a retrospective case series of patients with haemophilia A (conducted between December 2015 and October 2019), 10 patients aged 4 months–40 years [sexes not stated] were described, who developed acute septic arthritis, osteomyelitis, circulatory shock, compartment syndrome right forearm, bleeding left jaw pseudotumor, intracranial bleed, right thigh haematoma, post-trauma bleed or extensive haematoma of both forearms during treatment with factor-VIII for haemophilia A. All 10 patients, who had haemophilia A, were treated with factor-VIII [route and dosage not stated]. Subsequently, all patients developed acute haemostatic emergencies manifested as acute septic arthritis and osteomyelitis (1 patient), assaulted with circulatory shock (1 patient), compartment syndrome right forearm (1 patient), bleeding left jaw pseudotumor with circulatory shock (1 patient), intracranial bleed (3 patient), right thigh haematoma (1 patient), post-trauma bleed (1 patient) and extensive haematoma both forearms (1 patient) [durations of treatments to reactions onsets not stated]. Hence, all 10 patients received treatment with factor-VIII inhibitor bypassing fraction [FEIBA] for 2 weeks. Of these, three patients had undergone unspecified surgery. Three out of 10 patients also received treatment with eptacog-α [Novoseven] for 2 weeks. All patients had successful outcome after treatment. Sidharthan N, et al. Managing acute emergencies in Hemophilia A with inhibitors using bypassing agents - A tertiary care centre experience with resource limitations. 803503184 Haemophilia 26 (Suppl. 4): 30 abstr. MEDMP007497, Jun 2020. Available from: URL: https://onlinelibrary.wiley.com/toc/13652516/2020/26/S4 [abstract]

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Reactions 26 Sep 2020 No. 1823