Factors associated with pregnancy outcomes in women with a history of cerebral sinus venous thrombosis
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Factors associated with pregnancy outcomes in women with a history of cerebral sinus venous thrombosis Amihai Rottenstreich1 · Harel Gershgoren2 · Galia Spectre3,4 · Nael Da’as5 · Ohad S. Bentur4,6 · Gabriel Levin1 · Yosef Kalish7
© Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract To collect and summarize pregnancy outcomes among women with a history of cerebral sinus vein thrombosis (CSVT). A retrospective multicenter case–control study. The study group comprised all women diagnosed with CSVT during 2004–2018 at four university hospitals, and with follow-up data of pregnancy. A control group of women with a singleton pregnancy was established by matching, four-to-one, according to maternal age. The data of 74 pregnancies of 65 women with CSVT were analyzed. The median time-to-pregnancy interval from the CSVT was 4.2 [2.7–6.8] years. Anticoagulation therapy in the form of enoxaparin was administered in 68 (91.9%) pregnancies. Adjunctive low-dose aspirin was used throughout 12 (16.2%) pregnancies. Overall, 54 (73.0%) of the pregnancies ended in live births and 20 (27.0%) in miscarriage. The use of anticoagulation therapy during pregnancy was positively associated with live birth outcome (P
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