Factors Influencing the Success of In Vivo Sentinel Lymph Node Procedure in Colon Cancer Patients
- PDF / 173,536 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 94 Downloads / 268 Views
Factors Influencing the Success of In Vivo Sentinel Lymph Node Procedure in Colon Cancer Patients Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer Carsten T. Viehl • Ulrich Guller • Igor Langer Urban Laffer • Daniel Oertli • Markus Zuber
•
Published online: 26 January 2013 Ó Socie´te´ Internationale de Chirurgie 2013
Abstract Background The sentinel lymph node (SLN) procedure has the potential to provide relevant improvement in nodal staging in colon cancer patients. However, there remains room for improvement for SLN identification and sensitivity. Therefore, the objective of the present investigation was to analyze factors influencing the success of the SLN procedure in colon cancer patients. Methods One hundred seventy-four consecutive colon cancer patients were prospectively enrolled in this multicenter study and underwent in vivo SLN procedure with isosulfan blue 1 % followed by open standard oncologic colon resection. Several patient-, tumor-, and procedurerelated factors possibly influencing the SLN identification and sensitivity were analyzed.
C. T. Viehl (&) D. Oertli Department of Surgery, University Hospital Basel, 4031 Basel, Switzerland e-mail: [email protected] C. T. Viehl U. Laffer Department of Surgery, Hospital Center Biel, Biel, Switzerland U. Guller Division of Medical Oncology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland U. Guller University Clinic of Visceral Surgery and Medicine, University of Bern, Bern, Switzerland I. Langer Department of Surgery, Lindenhof Hospital, Bern, Switzerland M. Zuber Department of Surgery, Cantonal Hospital Olten, Olten, Switzerland
Results Sentinel lymph node identification rate and accuracy were 89.1 and 83.9 %, respectively. Successful identification of SLN was significantly associated with the intraoperative visualization of blue lymphatic vessels (p \ 0.001) and with female gender (p = 0.024). True positive SLN results were significantly associated with higher numbers of SLN (p = 0.026) and with pN2 stage (p = 0.004). There was a trend toward better sensitivity in patients with lower body mass index (BMI) (p = 0.050). Conclusions The success of the SLN procedure in colon cancer patients depends on both procedure-related factors (intraoperative visualization of blue lymphatic vessels, high number of SLN identified) and patient factors (gender, BMI). While patient factors can not be influenced, intraoperative visualization of blue lymphatics and identification of high numbers of SLN are key for a successful SLN procedure.
Introduction The sentinel lymph node (SLN) procedure has the potential to provide relevant improvement in nodal staging in colon cancer patients. Several multicenter studies, including our own, have shown that in-depth and focused analysis of SLN reveals small nodal tumor infiltrates in about 15 % of patients that were diagnosed node-negative in the initial routine hematoxylin & eosin (H&E) analysis [1–7]. While these findings are promising, there is still room for improvement regarding overall S
Data Loading...
