Feasibility and performance of lymphoscintigraphy in sentinel lymph node biopsy for early cervical cancer: results of th
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ORIGINAL ARTICLE
Feasibility and performance of lymphoscintigraphy in sentinel lymph node biopsy for early cervical cancer: results of the prospective multicenter SENTICOL study Anne-Sophie Bats • Albane Frati • Marc Froissart • Isabelle Orliaguet • Denis Querleu • Slimane Zerdoud • Eric Leblanc • He´le`ne Gauthier • Catherine Uzan • De´sire´e Deandreis • Emile Darai • Khaldoun Kerrou • Henri Marret • Emilie Lenain • Patrice Mathevet • Fabrice Lecuru Received: 28 May 2014 / Accepted: 18 September 2014 / Published online: 15 November 2014 Ó The Japanese Society of Nuclear Medicine 2014
Abstract Objective To evaluate feasibility, SLN detection rate, and SLN location of lymphoscintigraphy in sentinel lymph node (SLN) biopsy for early cervical cancer. Methods Ancillary analysis of data from the multicenter prospective SENTICOL study (January 2005–June 2007) of patients with early cervical cancer (FIGO stage IA with emboli to IB1) was conducted. Preoperative lymphoscintigraphy was performed after intracervical administration of 60 or 120 MBq of 99mTc-labeled radiocolloid on the day before (long protocol) or morning of (short protocol) surgery. SLNs were identified intraoperatively using
A.-S. Bats and A. Frati contributed equally to this work and should be considered co-first authors. A.-S. Bats F. Lecuru Faculte´ de Me´decine, Universite´ Paris Descartes, Sorbonne Paris Cite´, Paris, France A.-S. Bats (&) A. Frati F. Lecuru Chirurgie Cance´rologique Gyne´cologique et du Sein, Hoˆpital Europe´en Georges-Pompidou, Assistance Publique-Hoˆpitaux de Paris, 20-40 rue Leblanc, 75015, Paris, France e-mail: [email protected] A.-S. Bats F. Lecuru INSERM UMR-S 1124, Universite´ Paris Descartes, Sorbonne Paris Cite´, Paris, France M. Froissart Service de Me´decine Nucle´aire, Hoˆpital Europe´en GeorgesPompidou, Assistance Publique-Hoˆpitaux de Paris, Paris, France I. Orliaguet Me´decine Nucle´aire, Hoˆpital Edouard Herriot, Lyon, France D. Querleu Chirurgie Ge´ne´rale, Institut Claudius Regaud, Toulouse, France
combined radioactivity/patent blue detection. SLNs were sampled electively and routine bilateral pelvic lymphadenectomy was performed by laparoscopy. A centralized review of lymphoscintigraphies was performed to assess feasibility, detection rates, and anatomic SLN location. Results Of 139 patients included in the SENTICOL study, 133 received radiocolloid injection, and 131 (98.5 %) underwent preoperative lymphoscintigraphy, with the long protocol in three-fourths of cases. The lymphoscintigraphic detection rate was 87.8 %, with a median of 2 (1–4) SLNs per patient. By multivariate analysis, factors independently associated with lymphoscintigraphic SLN detection were age [odds ratio (OR) 0.91, 95 % confidence interval (95 % CI) 0.87–0.96; P \ 0.001], and protocol (long vs. short; OR 8.23, 95 % CI 1.87–36.25; S. Zerdoud Me´decine Nucle´aire, Institut Claudius Regaud, Toulouse, France E. Leblanc Chirurgie Ge´ne´rale, Center Oscar Lambret, Lille, France H. Gauthier Me´decine Nucle´aire, Center Oscar Lambre
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