Feasibility of studying the association between intraoperative regional cerebral oxygen saturation and postoperative fun
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REPORTS OF ORIGINAL INVESTIGATIONS
Feasibility of studying the association between intraoperative regional cerebral oxygen saturation and postoperative functional decline (ReFUNCTION): a pilot sub-study of NeuroVISIONCardiac Surgery Est-il faisable d’e´tudier l’association entre la saturation perope´ratoire en oxyge`ne ce´re´bral re´gional et le de´clin fonctionnel postope´ratoire (ReFUNCTION) ? Une sous-e´tude pilote de NeuroVISION-Cardiac Surgery . Andre Lamy, MD, MHSc, FRCSC . Jackie Bosch, PhD . Jessica Spence, MD, FRCPC Lehana Thabane, PhD . Stephanie Gagnon, BHSc . Patricia Power, MSc . Austin Browne, PhD . John Murkin, MD, FRCPC . P. J. Devereaux, MD, PhD, FRCPC Received: 1 March 2020 / Revised: 15 May 2020 / Accepted: 18 May 2020 Ó Canadian Anesthesiologists’ Society 2020
Abstract Purpose Function describes an individual’s ability to perform everyday activities. In the context of cardiac surgery, functional changes quantify the effect of surgery on one’s day-to-day life. Decreases in regional cerebral oxygen saturation (rScO2) measured using near-infrared spectroscopy (NIRS) has been associated with postoperative cognitive decline but its relationship with function has not been studied. We sought to determine the
feasibility of conducting a large observational study examining the relationship between decreases in rScO2 during cardiac surgery and postoperative functional decline. Methods We undertook a single-centre, pilot sub-study of the NeuroVISION-Cardiac Surgery pilot study, which included adults undergoing isolated coronary artery bypass grafting on cardiopulmonary bypass; all patients enrolled in NeuroVISION-Cardiac Surgery were included.
J. Spence, MD, FRCPC (&) Departments of Anesthesia and Critical Care and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, Canada e-mail: [email protected]
L. Thabane, PhD Population Health Research Institute, Hamilton, ON, Canada
Population Health Research Institute, Hamilton, ON, Canada
S. Gagnon, BHSc P. Power, MSc A. Browne, PhD Population Health Research Institute, Hamilton, ON, Canada
A. Lamy, MD, MHSc, FRCSC Population Health Research Institute, Hamilton, ON, Canada Departments of Surgery (Cardiac Surgery) and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, Canada J. Bosch, PhD Population Health Research Institute, Hamilton, ON, Canada School of Rehabilitation Science, McMaster University, Hamilton, Canada
Department of Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, Canada
J. Murkin, MD, FRCPC Department of Anesthesiology and Perioperative Medicine, University of Western Ontario, London, ON, Canada P. J. Devereaux, MD, PhD, FRCPC Population Health Research Institute, Hamilton, ON, Canada Departments of Medicine and Health Research Methods, Evaluation, and Impact, McMaster University, Hamilton, Canada
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Function was evaluated at baseline, 30 days, and three months using the Standardized Assessment of Global activities in the E
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