Features of aminalon drying in a pulsed bed reactor
- PDF / 155,358 Bytes
- 3 Pages / 595.276 x 793.701 pts Page_size
- 18 Downloads / 190 Views
FEATURES OF AMINALON DRYING IN A PULSED BED REACTOR M. S. Vasilishin,1,* O. S. Ivanov,1 A. A. Kukhlenko,1 Z. B. Podsevalova,2 and A. G. Karpov1 Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 8, pp. 54 – 56, August, 2012. Original article submitted July 8, 2011.
The influence of various processing parameters on the drying kinetics of pharmaceutical aminalon in a pulsed bed apparatus was investigated. The results could be used to design commercial drying equipment. Key words: aminalon (g-aminobutyric acid), drying, pulsed bed reactor
gas-distribution grids that enabled the fraction of active cross section to be varied in the range 0.1 – 0.3. The vertical section of the operating chamber had a removable cover for taking samples of the dried material. The drying agent (air) was continuously supplied using a rotary electrical mechanical pulsed valve (2) with an electronic control system (3) and gas blower (4). Air was heated in an electric furnace (5). Spent drying agent was cleaned of product dust in a sleeve filter (6) to which a removable container (7) was attached for collecting removed product dust. The filter was connected to a tail fan (8) that removed spent air from the apparatus. The parameters that had the greatest effect on the pseudo-liquefaction of the layer of dispersed material and its drying kinetics were monitored during the course of the experiment. The air pressure in the main manifold was controlled by a micromanometer (9); its flow rate, by a Testo-425 thermal anemometer (Germany). Expansion of the bed was evaluated visually using a scale fixed on the wall of the apparatus operating chamber; its resistance, by a differential manometer (10). The air temperature at the entrance to the dryer was maintained using a thermal relay in combination with a thermal sensor set under the gas-distribution grid of the dryer. The aminalon bed temperature was recorded remotely by a Piton-102 optical infrared pyrometer (Russia). The moisture content of the material was determined using an MV-23 humidity analyzer (Ohaus Instruments, Switzerland). The starting material was pharmacopoeial I manufactured according to FSP 42-00-34632205 (Organika). The product was characterized by the actual density r = 1230 kg/m3, bulk density rb = 390 kg/m3, equivalent particle di-
Aminalon (g-aminobutyric acid, I) is broadly used in medical practice as a nootropic agent that enhances the restoration of metabolic processes in the brain and affects favorably the recovery of motion and speech after brain blood circulation disorders [1]. Qualitative indicators of a product that satisfies pharmacopoeial requirements are defined to a large extent by the effectiveness of its drying, which is carried out under industrial production conditions by periodic processing in circulation dryers at 75-80°C. The process typically takes a long time, which often leads to a poor quality dry product and is labor intensive. Better drying of I and its improved quality are directly related to the implementation of progressive technologies
Data Loading...
