First case of Candida auris isolated from the bloodstream of a Mexican patient with serious gastrointestinal complicatio
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BRIEF REPORT
First case of Candida auris isolated from the bloodstream of a Mexican patient with serious gastrointestinal complications from severe endometriosis J. Jacobo Ayala‑Gaytán1 · Alexandra M. Montoya2 · Michel F. Martínez‑Resendez3 · Claudia E. Guajardo‑Lara4 · Rogelio de J. Treviño‑Rangel2 · Lorena Salazar‑Cavazos2 · Jorge M. Llaca‑Díaz2 · Gloria M. González2 Received: 3 August 2020 / Accepted: 12 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract A 58-year-old woman was diagnosed with severe endometriosis and had multiple gastrointestinal tract complications for many years. Candida auris and C. parapsilosis were isolated from the bloodstream. Identification of C. auris was confirmed by amplification and sequencing of the internal transcriber spacer and the D1/D2 domain of the large rRNA gene subunit. Antifungal susceptibility was tested in both isolates using the Clinical Laboratory Standards Institute protocol M27-A3/S4. The patient evolved favorably with systemic antifungal therapy consisting of caspofungin and liposomal amphotericin B. Keywords Candida auris · Endometriosis · Susceptibility · Clinical case · Lytic enzymes · Identification
Introduction Candida auris was first isolated from the secretion of the external ear canal of a female patient in 2009 [1]. Since then, many communications have suggested the involvement of this yeast in numerous medical conditions, including severe diseases. Bloodstream infections are the most frequent invasive illnesses with in-hospital mortality rates of up to 70% J. Jacobo Ayala-Gaytán and Alexandra M. Montoya should be considered joint first author. * Gloria M. González [email protected] 1
Infectious Disease Service, Hospital San Jose, TecSalud, Av. Morones Prieto #3000 Pte, Col. Los Doctores, 64710 Monterrey, Nuevo Leon, Mexico
2
Microbiology Department, Universidad Autonoma de Nuevo Leon Facultad de Medicina y Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Av. Madero y Calle Dr. Eduardo Aguirre Pequeño s/n, Colonia Mitras Centro, 64460 Monterrey, Nuevo Leon, Mexico
3
Epidemiological Surveillance Unit, Hospital San Jose, TecSalud, Av. Morones Prieto #3000 Pte, Col. Los Doctores, 64710 Monterrey, Nuevo Leon, Mexico
4
Clinical Microbiology Laboratory, Hospital San José, TecSalud, Av. Morones Prieto #3000 Pte, Col. Los Doctores, 64710 Monterrey, Nuevo Leon, Mexico
[2]. Infections with C. auris generally involve patients with underlying medical comorbidities and noteworthy healthcare exposure, with infections classically taking place weeks after hospital admission [2, 3]. However, isolation of this yeast in clinical specimens is likely underestimated largely because it is not achievable to characterize C. auris using manual or commercial biochemical recognition systems, which are mainly used in conventional clinical laboratories [4]. Candida auris is recognized as an emerging multidrug-resistant yeast and its correct identification is crucial for appropriate therapy. Herein, we report the first
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