• PDF / 183,082 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 88 Downloads / 246 Views

DOWNLOAD

REPORT

---

1 S

Catheter-related Malassezia furfur colonisation and fungaemia: 20 case reports In a retrospective descriptive study of 20 neonates conducted between April 2005 to October 2016 at a neonatal intensive care unit (NICU) of Kaohsiung Chang Gung Memorial Hospital (KCGMH) in Taiwan, 20 neonates (11 male and 9 female) born at gestational age of 24+3–31+1 weeks were described. Of the 20 neonates, 18 neonates developed catheter-related Malassezia furfur colonisation while being treated with fluconazole and soya-oil-emulsion/medium-chain-triglyceride/olive-oil/fish-oil. One neonate (patient 3) developed catheter-related Malassezia furfur colonisation while being treated with soya-oil emulsion/medium-chaintriglyceride/olive-oil/fish-oil. The remaining male neonate (patient 16) developed Malassezia furfur fungaemia while being treated with fluconazole and soya-oil-emulsion/medium-chain-triglyceride/olive-oil/fish-oil [not all dosages, indication, route and time to reaction onset stated, outcomes not stated]. All the 20 neonates received soya-oil-emulsion/medium-chain-triglyceride/olive-oil/fish-oil (SMOF) for the duration of 9–102 days. All of them received unspecified broad spectrum antibiotic concomitantly. Out of 20 neonates, 19 neonates received prohylactic fluconazole at a dose of 6 mg/kg every 72 hours (except patient 3, male neonate born at 28+5 weeks of gestational age and BBW of 1140g who did not undergone central catheter placement immediately after birth). All neonates underwent phototherapy for neonatal jaundice. Of the 20 neonates, 19 neonates developed catheter-related Malassezia furfur colonisation with positive tip cultures and negative blood culture, their initial management included percutaneous central venous catheter (pCVC) removal. One male neonate (patient 16, born at 28+6 weeks of gestational age) developed Malassezia furfur fungaemia. The male neonate with Malassezia furfur fungaemia presented some nonspecific symptoms including bradycardia, apnea and thrombocytopenia. This male neonate (patient 16) received treatment with amphotericin B (1 mg/kg/d) and required a longer duration of total parenteral nutrition support due to feeding intolerance during the period of the invasive infection. All the 20 neonates survived and were discharged. Chen IT, et al. Malassezia furfur Emergence and Candidemia Trends in a Neonatal Intensive Care Unit During 10 Years: The Experience of Fluconazole Prophylaxis in a 803520712 Single Hospital. Advances in Neonatal Care 20: E3-E8, No. 1, Feb 2020. Available from: URL: http://doi.org/10.1097/ANC.0000000000000640

0114-9954/20/1834-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 12 Dec 2020 No. 1834