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Nausea and diarrhoea: case report A 68-year-old woman developed nausea and diarrhoea during treatment with fluorouracil, folinic acid and irinotecan for metastatic rectal adenocarcinoma. The woman was diagnosed with stage IIA colorectal adenocarcinoma in September 2010, for which abdominoperineal resection was performed. Following surgery, she received FOLFOX regimen comprising of oxaliplatin, 5‑fluorouracil [5‑fluorouracil] and folinic acid [leucovorin]. Her disease remained progressionfree for 6 years. In February 2017, she presented with rapidly progressing pruritic skin lesions on her neck and chest and neck for 1 month. After subsequent investigations, she was diagnosed with metastatic rectal adenocarcinoma to the breast and skin. She received four cycles of FOLFIRI regimen comprising of fluorouracil, folinic acid and irinotecan [routes and dosages not stated]. Following treatment, a marked improvement was observed in cutaneous lesions of the neck and chest and in breast tumour. However, she developed grade IV adverse effects including nausea and diarrhoea. These adverse effects led to poor compliance to the treatment [time to reaction onset and outcomes not stated]. The woman’s treatment with FOLFIRI regimen was stopped. She refused an alternative treatment with FOLFOX regimen. In May 2017, she died due to multiple visceral metastases. Author comment: "The patient received four cycles of [fluorouracil, folinic acid and irinotecan] chemotherapy, with marked improvement of the breast tumor and cutaneous lesions on the chest and neck. Unfortunately, the patient suffered grade IV adverse effect include nausea and diarrhea during chemotherapy with resulting poor compliance." Liao X-Y, et al. Cutaneous and breast metastasis from colorectal adenocarcinoma: A rare case report. Molecular and Clinical Oncology 11: 143-146, No. 2, Aug 2019. Available from: URL: http://doi.org/10.3892/mco.2019.1866 803437674 China

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Reactions 7 Dec 2019 No. 1782