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Neuropathy: case report A 75-year-old man developed neuropathy during treatment with fluorouracil and trastuzumab for adenocarcinoma. The man presented with dry cough and upper abdominal discomfort. Subsequent analyses led to the diagnosis of adenocarcinoma with HER-2 (human epidermal growth factor receptor-2) expression. Therefore, he underwent 9 cycles of the FOLFOX regimen, comprising folinic acid, fluorouracil and oxaliplatin along with trastuzumab, with marked improvement. The regimen was later modified to fluorouracil [5-fluorouracil] and trastuzumab [dosages and routes not stated], and he received an additional 63 cycles of chemotherapy over 34 months. A satisfactory response to the treatment was noted; although hepatic nodules remained stable, the gastric lesions continued to grow. Hence, he underwent partial gastrectomy with D2 lymphadenectomy and Roux-en-Y reconstruction. Chemotherapy was resumed post-operatively, and he continued to receive same regimen. Subsequently, he developed minor toxicity-related symptoms of grade I neuropathy [durations of treatments to reaction onset not stated]. However, he was content with the treatment, and no further disease progression was noted until the last follow-up [outcome not stated]. Takeda FR, et al. Primary tumor resection of metastatic gastric cancer in a multimodal era: Two case reports. International Journal of Surgery Case Reports 75: 42-45, 2020. 803505822 Available from: URL: http://doi.org/10.1016/j.ijscr.2020.08.033

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Reactions 10 Oct 2020 No. 1825