Folate levels in hepatocellular carcinoma patients with portal vein thrombosis
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RESEARCH ARTICLE
Folate levels in hepatocellular carcinoma patients with portal vein thrombosis Giulia Malaguarnera1 , Vito Emanuele Catania2* , Saverio Latteri2, Antonio Maria Borzì3 , Gaetano Bertino4 , Roberto Madeddu5 , Filippo Drago1 and Michele Malaguarnera3
Abstract Background: Portal vein thrombosis (PVT) occurs frequently in hepatocellular carcinoma (HCC) and is often diagnosed in the course of a routine patient evaluation and surveillance for liver cancer. The purpose of this study is to investigate the relationship between folate status and portal vein thrombosis. Methods: HCC with PVT patients were 78, HCC without PVT were 60 and control subjects were 70 randomly selected. We evaluate serum and red blood cellular folate, homocysteine, alpha fetal protein cholesterol, triglycerides, prothrombin time. Results: HCC patients with PVT showed lower levels of serum folate, respect HCC patients without PVT, with an average difference of 1.6 nmol/l p
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