Frailty in Older Dialysis Patients
In older patients with chronic kidney disease (CKD), the issue of frailty emerges as a challenging condition, from multiple points of view: first, CKD is an accelerator of aging (via deleterious processes like protein-energy wasting and chronic inflammati
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Frailty and Kidney Disease
Carlos Guido Musso • José Ricardo Jauregui Juan Florencio Macías-Núñez • Adrian Covic Editors
Frailty and Kidney Disease A Practical Guide to Clinical Management
Editors Carlos Guido Musso Hospital Italiano de Buenos Aires Buenos Aires Argentina
José Ricardo Jauregui Hospital Italiano de Buenos Aires Buenos Aires Argentina
Juan Florencio Macías-Núñez University of Salamanca Salamanca Spain
Adrian Covic Grigore T. Popa University of Medicine Iasi Romania
ISBN 978-3-030-53528-5 ISBN 978-3-030-53529-2 (eBook) https://doi.org/10.1007/978-3-030-53529-2 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
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Foreword
Frailty is a geriatric syndrome, not a specific disease, that is defined by a number of clinical manifestations, including unintentional weight loss, declining strength, and low physical activity. It can be recognized by application of several well-established and validated scoring systems. It is common among the elderly and very elderly, and accounts for substantial morbidity and mortality, especially due to falls and delayed recovery from inter-current illnesses. Frailty is a dynamic process, and at the individual level, its status can change dramatically over time. Pathophysiologically, muscle loss (sarcopenia) and bone fragility (osteopenia) contribute greatly to the origins of the syndrome. While frailty has received great attention in the geriatric literature, it has received only scanty and superficial scrutiny by the discipline of nephrology. This deficiency has now been corrected by Carlos G. Musso, MD, PhD, and his collaborators by the publication of this treatise dedica
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