Frequent occurrence of hypophosphatemia among multiple myeloma patients treated with elotuzumab: a single clinic retrosp
- PDF / 335,200 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 29 Downloads / 176 Views
ORIGINAL ARTICLE
Frequent occurrence of hypophosphatemia among multiple myeloma patients treated with elotuzumab: a single clinic retrospective study Bernard Regidor 1 & Regina Swift 1 & Benjamin Eades 1 & Marsiye Emamy-Sadr 1 & Fadi Tarhini 1 & Tanya M. Spektor 2 & James R. Berenson 1,2,3 Received: 13 May 2020 / Accepted: 12 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The purpose of this single-center retrospective study was to determine the incidence of decreased blood phosphorus levels and hypophosphatemia among multiple myeloma (MM) patients treated with elotuzumab. Hypophosphatemia, which is defined as a serum phosphorus concentration < 2.5 mg/dL, leads to complications ranging from muscle weakness and disorientation to seizures and heart failure. A total of 23 MM patients receiving care in a clinic specializing in treatment of MM from July 2018 to March 2020 and treated with an elotuzumab-containing therapy were evaluated, and 9 were investigated for this study. Elotuzumab was given at 10 mg/kg weekly for the first two treatment cycles (28 days/cycle), followed by 10 mg/kg every other week for all subsequent cycles. Four different elotuzumab combination therapies were administered: 1) elotuzumab and dexamethasone 2) elotuzumab, lenalidomide and dexamethasone 3) elotuzumab, pomalidomide and dexamethasone and 4) elotuzumab, carfilzomib, pomalidomide, and dexamethasone. Phosphorous levels were determined at a median of every 13 days at intervals ranging from once weekly to once monthly until a phosphate supplement was prescribed to the patient or when elotuzumab treatment was discontinued. We found that regardless of elotuzumab combination therapy, all patients treated showed decreased phosphorus levels after initiating elotuzumab treatment with reductions ranging from 12.5% to 44.1% below baseline. Six participants (67%) demonstrated an average serum phosphorus at or below 2.5 mg/dL after starting elotuzumab therapy. This retrospective study suggests that hypophosphatemia commonly occurs among MM patients receiving elotuzumabcontaining therapies. Keywords Multiple myeloma . Elotuzumab . Hypophosphatemia . Decreased phosphorus
Introduction Multiple myeloma (MM) is a disease of the bone marrow characterized by malignant plasma cells that produce monoclonal antibodies [1]. Treatment for MM includes use of immunomodulatory drugs, proteasome inhibitors, chemotherapies, alkylating agents, and more recently antibody-based
* James R. Berenson [email protected] 1
James R. Berenson, MD, Inc., West Hollywood, CA 90069, USA
2
Oncotherapeutics, , West Hollywood, CA 90069, USA
3
Institute for Myeloma & Bone Cancer Research, 9201 W. Sunset Blvd., Suite 300, West Hollywood, CA 90069, USA
therapies. The monoclonal antibody elotuzumab induces antibody-dependent cellular cytotoxicity (ADCC) by activating natural killer (NK) cells and also targets directly MM cells for destruction via the targeting of the signaling lymphocyte activation member family (SLAMF)7 glycoprotein which i
Data Loading...
