Frontiers in Biosensorics II Practical Applications

Volume II focuses on the state-of-the-art technologies and applications of various types of sensors. It presents different analyzers and their operational parameters in many areas of practical use. Moreover, aspects of the marketability of biosensors are

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Frontiers in Biosensorics II Practical Applications Edited by F. W Scheller F. Schubert J. Fedrowitz

Birkhauser Verlag Basel . Boston~· Berlin

Editors Prof. Dr. F. W. Scheller Institut fiir Biochemie und Molekulare Physiologie clo Max-Delbriick-Centrum fiir Molekulare Medizin Robert-Rossle-Strasse 10 D-13122 Berlin

Dr. F. Schubert Physikalisch-Technische Bundesanstalt Abbestrasse 2-12 D-I0587 Berlin

Dr. 1. Fedrowitz c/o Centrum fiir Hochschulentwicklung PO Box 105 D- 33311 Giitersloh Library of Congress Cataloging-in-Publication Data A CIP catalogue record for this book is available from the library of Congress, Washington D. C., USA

Deutsche Bibliothek Cataloging-in-Publication Data EXS. - Basel; Boston; Berlin: Birkauser. Friiher Schriftenreihe Fortlaufende Beil. zu: Experientia 81. Frontiers in Biosensorics. 2. Practical applications. - 1997 Frontiers in Biosensorics 1 ed. by. F. W. Scheller ... - Basel; Boston; Berlin: Birkhauser. (EXS; 81) ISBN-13: 978-3-0348-9884-3 e-ISBN-13: 978-3-0348-9045-8 DOl: 10.1007/978-3-0348-9045-8 NE: Scheller, Frieder [Hrsg.] 2. Practical applications. - 1997 Practical applications. - Basel; Boston; Berlin: Birkliuser. 1997 (Frontiers in Biosensorics; 2) (EXS; 81) ISBN-13: 978-3-0348-9884-3 The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of iIlustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use permission of the copyright owner must be obtained. © 1997 BirkhauserVerlag, PO Box 133, CH-4010 Basel, Switzerland Softcover reprint of the hardcover 1st edition 1997 Printed on acid-free paper produced from chlorine-free pulp. TCF 00 ISBN-13:978-3-0348-9884-3 987654321

Contents

A. Brecht and G. Gauglitz Reflectometric interference spectroscopy for direct affinity sensing

c.J. McNeil, D. Athey and R. Renneberg Immunosensors for clinical diagnostics . .

17

E Spener, M. Meusel and C. Siegmann-Thoss Biosensors based on flow-through systems .

27

U Wollenberger, E Lisdat and E W. Scheller Enzymatic substrate recycling electrodes

45

B. Danielsson and B. Xie Thermistor-based biosensing

71

I lliev and A. Kaisheva Electrochemical gas biosensors

87

K. Riedel Microbial BOD sensors: Problems of practical use and comparison of sensorBOD and BODs . . . . . . . . . . . . . . . . . . . . . .

99

P.-D. Hansen andA. v. Usedom New biosensors for environmental analysis

109

A. Warsinke Biosensors for food analysis

121

H Luedi Challenges in th