Functional human brain connectivity during labor and its alteration under epidural analgesia
- PDF / 2,682,478 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 94 Downloads / 202 Views
ORIGINAL RESEARCH
Functional human brain connectivity during labor and its alteration under epidural analgesia Fan-Pei Yang 1 & An-Shine Chao 2 & Sung-Han Lin 3 & Anne Chao 4 & Tzu-Hao Wang 2 & Yao-Lung Chang 2 & Hong-Shiu Chang 5 & Jiun-Jie Wang 3,6,7
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract This study used functional magnetic resonance imaging to explore the neural networks of pain during labor and its relief. It was hypothesized that epidural analgesia would affect the neural activities and the underlying network connectivity. Analysis using dynamic causal modelling and functional connectivity was performed to investigate the spatial activity and network connection of labor pain with and without epidural analgesia. This Institutional Review Board approved study acquired Magnetic Resonance Imaging from 15 healthy women of spontaneous normal delivery (with/without epidural analgesia = 7/8, aged 29.6 ± 2.3 and 29.3 ± 4.8 years old respectively) using a 1.5 Tesla scanner. Numerical rating score of pain was evaluated by a research nurse in the beginning of the first stage of labor and approximately 30 min after imaging examination. Six regions of interested from the activated clusters and literature were selected for dynamic causal modelling, which included primary and secondary somatosensory cortex, middle frontal gyrus, anterior cingulate cortex, insula and lentiform. Functional connectivity was calculated from selected sensory and affective regions. All analyses were performed by using software of statistical parametric mapping version 8 and CONN functional connectivity toolbox. The result showed that the experience of labor pain can lead to activations within a distributed brain network. The pain relief from epidural analgesia can be accompanied with altered functional connectivity, which was most evident in the cingulo-frontal system. The present study, therefore, provides an overview of a pain-related neural network that occur during labor and upon epidural analgesia. Keywords Labor pain . Connectivity networks . Functional magnetic resonance imaging . Dynamic causal modelling . Normal delivery . Epidural analgesia
Fan-Pei Yang and An-Shine Chao contributed equally to this work. * Jiun-Jie Wang [email protected] 1
Department of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, Taiwan
2
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan
3
Department of Medical Imaging and Radiological Sciences, Chang Gung University, 259 WenHua 1st Road, TaoYuan county, Taiwan
4
Department of Anesthesia, National Taiwan University Hospital, Taipei, Taiwan
5
Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan
6
Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan
7
Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan
Introduction Labor pain is typically a very strong sensory stimulus
Data Loading...
