Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug Delivery
Current chapter contains fundamentals of drug delivery systems and different means for transferring drugs to the targeted organs. This chapter explains the synthesis of poly caprolactone triol-co-citric acid (PCLT-CA) in different compositions and subsequ
- PDF / 628,618 Bytes
- 14 Pages / 439.37 x 666.142 pts Page_size
- 84 Downloads / 211 Views
Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug Delivery
Abstract Current chapter contains fundamentals of drug delivery systems and different means for transferring drugs to the targeted organs. This chapter explains the synthesis of poly caprolactone triol-co-citric acid (PCLT-CA) in different compositions and subsequent processing of the polymerized materials into the elastomeric films and coatings for drug delivery applications. A detailed MALDI-ToF-MS analysis was performed on different compositions of PCLT-CA as well as PCLT as a control. Confirmation of a progressive pre-polymerization was obtained by the help of MALDI analysis. In the current chapter, formation of the branched molecules of this polymer system, end-group analysis and structural analysis of the compositions are explained in a great detail. Moreover, application of developed materials in the field of drug delivery is discussed in regards to the chemical and mechanical properties of the synthesized copolymer compositions. Key aspects in biomaterials study such as degradation rate and kinetic of the drug release were chosen as the major focus areas in this chapter. Current chapter is dedicated to the MALDI analysis of a branched copolymer system with 2 monomers involved in synthesis reaction.
Keywords Drug delivery Elastomeric films Coatings Drug release kinetic Mechanical property Chemical property Degradation rate
4.1
Drug Delivery
Drug delivery, in principle, refers to variety of approaches that are applied for transferring specific pharmaceutical compounds to the targeted organs. Throughout its journey, drug on delivery has to safely arrive to its destination and performs its expected therapeutic role [1]. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Drug release,
© The Author(s) 2017 S. Hosseini and S.O. Martinez-Chapa, Fundamentals of MALDI-ToF-MS Analysis, SpringerBriefs in Forensic and Medical Bioinformatics, DOI 10.1007/978-981-10-2356-9_4
53
54
4 Fundamentals of Drug Delivery Systems and Application …
normally, occurs through diffusion, degradation, swelling and affinity-based systems [2]. In any case, both quantity and duration of the drug release play the most important roles. The most common routes for drug delivery are: (i) oral (through the mouth); (ii) transdermal (through the skin); (iii) transmucosal (through nasal, sublingual, ocular etc.); and (iv) inhalation [3]. Figure 4.1 depicts a schematic representation of the drug delivery via transdermal route as an example. As it can be seen in Fig. 4.1, synthetic material in the form of the patch is loaded with specific drugs. Drugs are located inside the gaps between the cross-links. Upon connection with the skin, cross-links break and drugs can be released. Depending on the type of applied materials, drug release happens due to the change in the temperature or pH of the body. Nu
Data Loading...
