Future Directions in Molecular Imaging
After the identification of new genes, functional information is required to investigate the role of these genes in living organisms. This can be done by analysis of gene expression, protein—protein interaction, or biodistribution of new molecules and may
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Springer-Verlag Berlin Heidelberg GmbH
Ernst Schering Research Foundation Workshop 48
From Morphological Imaging to Molecular Targeting Implications to Preclinical Development M. Schwaiger, L. Dinkelborg, H. Schweinfurth Editors
With 20 Figures
Springer
Series Editors: G. Stock and M. Lessl
ISSN 0947-6075 ISBN 978-3-662-07312-4 Library of Congress Cataloging-in-Publication Data From morphological imaging to molecular targeting: implications for preclinical developmentIM. Schwaiger, L. Dinkelborg, and H. Schweinfurth. p.; em. - (Ernst Schering Research Foundation workshop, ISSN 0947-6075; 48) Includes bibliographical references and index. ISBN 978-3-662-07312-4 ISBN 978-3-662-07310-0 (eBook) DOI 10.1007/978-3-662-07310-0 1. Radiopharmaceuticals - Congresses. 2. Drug targeting - Congresses. 3. Ligand binding (Biochemistry) - Congresses. 4. Drugs - Design - Congresses. 1. Schwaiger, Markus. II. Dinkelborg, L. (Ludger), 1962- III. Schweinfurth, H. (Hennann), 1950- IV. Series. [DNLM: I. Drug Evaluation, Preclinical - Congresses. 2. Radiopharmaceuticals Congresses. 3. Clinical Trials - Congresses. 4. Drug Delivery Systems - methods Congresses. 5. Drug Design - Congresses. QV 771 M871 2004] This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the Gennan Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag Berlin Heidelberg GmbH. Violations are liable for prosecution under the Gennan Copyright Law. springeronline.com © Springer-Verlag Berlin Heidelberg 2004 Originally published by Springer-Verlag Berlin Heidelberg New York in 2004 Softcover reprint of the hardcover 1st edition 2004 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: design & production GmbH, Heidelberg Typesetting: K + V Fotosatz GmbH, Beerfelden 2113l30/AG-5 4 3 2 1 0 - Printed on acid-free paper
Preface
Because of the current progress in molecular medicine (genomics, proteomics), a plethora of new and often human-specific targets are being identified. These targets often play a significant role in the pathogenesis of diseases, and identifying them offers the potential for early diagnosis and intervention. An early in vivo validation of specific ligands binding to these targets in humans i
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