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Delayed posterior reversible encephalopathy syndrome: case report A 62-year-old man was diagnosed with bladder cancer and underwent surgery. Metastases occurred after 2 years and he received gemcitabine and oxaliplatin every 21 days [dosages not stated]. He developed generalised seizures 6 weeks after the sixth administration. Neurological examination revealed difficulty following commands and abnormal mental status. He had increased deep tendon reflexes and increasing plantar responses. His BP, which was 145/85mm Hg on admission, was moderately increased (160/90mm Hg) during his hospitalisation. A brain MRI revealed a symmetrical, highintensity signal in his cortex and subcortical white matter affecting his occipital and parietal lobes and cerebellar hemispheres. His condition improved over several days with supportive care, but he died from aspiration pneumonia 2 weeks after hospitalisation. Author comment: The "known association between platinum based cytotoxic agents and delayed [posterior reversible encephalopathy syndrome] lead us to consider this case as a complication of oxaliplatin therapy as a similar neurotoxic syndrome to the closely related cisplatin". Mor´ıs G, et al. Delayed posterior encephalopathy syndrome following chemotherapy with oxaliplatin and gemcitabine. Journal of Neurology 254: 801090215 534-535, No. 4, Apr 2007 - Spain

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Reactions 28 Jul 2007 No. 1162