Genetically Engineered Mice for Cancer Research design, analysis, pa
Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors. This book provides
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Jeffrey E. Green
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Thomas Ried
Editors
Genetically Engineered Mice for Cancer Research Design, Analysis, Pathways, Validation and Pre-Clinical Testing
Editors Jeffrey E. Green Transgenic Oncogenesis and Genomics Section Laboratory of Cancer Biology and Genetics National Cancer Institute Bethesda, MD, USA [email protected]
Thomas Ried Genetics Branch, Center for Cancer Research, National Institutes of Health/National Cancer Institute Bethesda, MD, USA [email protected]
ISBN 978-0-387-69803-8 e-ISBN 978-0-387-69805-2 DOI 10.1007/978-0-387-69805-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011939084 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
The extraordinary explosion in our knowledge about cancer over the last 40 years has finally begun to illuminate the black box that defines what we now know to be a large collection of distinct but highly related diseases called cancer. Our knowledge is far from complete-insights, surprises and alternate views still await us as our journey through cancer research continues. Despite this progress, the speed and extent of advances in our ability to prevent and treat cancer is frustrating to all. Much is now discussed about the need to emphasize the translation of our fundamental insights into new approaches to people with cancer. This book and the efforts described are essentially about that translational challenge. There are two critical roadblocks to translate basic research into new cancer interventions: 1. It is essential that we can definitely relate and apply our knowledge gained in the laboratory to the actual human disease as it exists in people with cancer and 2. We need a very robust translational enterprise that links the discovery, development, and testing of safe and effective interventions, such as diagnostics and drugs, to the relevant science The modern use of mouse models for human cancer is critical to both of these roadblocks. Unfortunately, the very term “mouse models” tends to imply a somewhat limited view of the potential of the mouse for teaching us about cancer. First of all, mice can get cancer and they can be experimentally manipulated to get cancer. This, in and of itself, provides us
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