Genome Integrity
Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assa
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Genome Integrity Facets and Perspectives Volume Editor: Dirk-Henner Lankenau
With 60 Figures
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Series and Volume Editor: Priv.-Doz. Dr. Dirk-Henner Lankenau Hinterer Rindweg 21 68526 Ladenburg Germany e-mail: [email protected]
Cover The cover illustration depicts two key events of DNA repair: 1. The ribbon model shows the structure of the termini of two Rad50 coiled-coil domains, joined via two zinc hooks at a zentral zinc ion(sphere). The metal dependent joining of two Rad50 coiled-coils is a central step in the capture and repair of DNA double-strand breaks by the Rad50/Mre11/Nbs1 (MRN) damage sensor complex. 2. Immunolocalization of histone variant γ -H2Av in γ -irradiated nuclei of Drosophila germline cells. Fluorescent foci indicate one of the earliest known responses to DNA double-strand break formation and sites of DNA repair. (provided by Karl-Peter Hopfner, Munich and Dirk-Henner Lankenau, Heidelberg)
Library of Congress Control Number: 2006935268
ISSN 1861-3373 ISBN-10 3-540-37528-7 Springer Berlin Heidelberg New York ISBN-13 978-3-540-37528-9 Springer Berlin Heidelberg New York DOI 10.1007/b104871
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com c Springer-Verlag Berlin Heidelberg 2007 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Editor: Dr. Sabine Schreck Desk Editor: Ursula Gramm, Heidelberg Cover figures: Prof. Karl-Peter Hopfner and Dr. Dirk-Henner Lankenau Cover design: WMXDesign GmbH, Heidelberg Typesetting and Production: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper 02/3100 YL – 5 4 3 2 1 0
Preface
Genome dynamics and stability are the non plus ultra requirements for cellular life. No matter whether life began with metabolism, with self-replicating genetic molecules, or as a cooperative chemical phenomenon, all cells and viruses maintain a genome capable of multiplication, variation and heredity. A population of living entities with these properties will evolve by natural selection, and while modern metabolism supplies the monomers from which genomes (i.e. replicators) are made, genomes alter the kinds of chemical reactions occurring in metabolism (Maynard Smith and Szathmary 1997). This book deals with DNA repair and replication. Together with two other planned volume
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