Genomic Applications in Pathology
Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by curre
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Genomic Applications in Pathology
George J. Netto • Iris Schrijver Editors
Genomic Applications in Pathology
Editors George Jabboure Netto Departments of Pathology, Oncology and Urology Johns Hopkins University Baltimore, MD, USA
Iris Schrijver Department of Pathology Stanford University School of Medicine Stanford, CA, USA
ISBN 978-1-4939-0726-7 ISBN 978-1-4939-0727-4 (eBook) DOI 10.1007/978-1-4939-0727-4 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014940289 © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The pathologist has an increasingly central role in the management of cancer patients in the era of personalized oncology. Molecular diagnostic and genomic applications are rapidly penetrating the daily practice of the pathologist as the list of actionable genetic alterations in solid and hematologic malignancies continues to expand. At the same time, a paradigm shift in the diagnostic approach for inherited genetic diseases, infectious diseases, and pharmacogenetics is unfolding. As a result, a plethora of clinical genomic applications is being rapidly implemented in diagnostic molecular pathology laboratories as we move closer to the anticipated reality
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