Global Tracking in Human Gliomas: A Comparison with Established Tracking Methods
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O r i g i n a l A rt i c l e
Global Tracking in Human Gliomas: A Comparison with Established Tracking Methods T. Nguyen-Thanh · M. Reisert · C. Anastasopoulos · F. Hamzei · T. Reithmeier · M. S. Vry · V. G. Kiselev · A. Weyerbrock · I. Mader
Received: 18 October 2012 / Accepted: 2 January 2013 © The Author(s) 2013. This article is published with open access at Springerlink.com
Abstract Purpose Global tracking (GT) is a recently published fibre tractography (FT) method that takes simultaneously all fiI. Mader () · T. Nguyen-Thanh · C. Anastasopoulos Department of Neuroradiology, University Medical Centre Freiburg, Breisacher St. 64, 79106 Freiburg, Germany e-mail: [email protected] T. Nguyen-Thanh Department of Radiology, Hue University College of Medicine and Pharmacy, Hue, Vietnam e-mail: [email protected] C. Anastasopoulos Clinic of Neuropediatrics and Muscular Diseases, University Medical Centre Freiburg, Mathildenst. 1, 79106 Freiburg, Germany M. Reisert · V. G. Kiselev Department of Radiology, Medical Physics, University Medical Centre Freiburg, Freiburg, Germany F. Hamzei Gräfliche Kliniken Moritz Klinik GmbH & Co. KG, Bad Klosterlausnitz, Germany F. Hamzei · M. S. Vry Department of Neurology, University Medical Centre Freiburg, Freiburg, Germany T. Reithmeier Department of Stereotactic and Functional Neurosurgery, University Medical Centre Freiburg, Freiburg, Germany T. Reithmeier Clinic of Neurosurgery, Munich Municipal Hospital Group, Englschalkinger St. 77, 81925 Munich, Germany
bres into account during their reconstruction. The purpose of this study was to compare this new method with fibre assignment by continuous tracking (FACT) and probabilistic tractography (PT) for the detection of the corticospinal tract (CST) in patients with gliomas. Methods Tractography of the CST was performed in 17 patients with eight low grade and nine anaplastic astrocytomas located in the motor cortex or the corticospinal tract. Diffusions metrics as fractional anisotropy (FA), mean (MD), axial (AD) and radial diffusivity (RD) were obtained. The methods were additionally applied on a physical phantom to assess their accuracy. Results PT was successful in all (100 %), GT in 16 (94 %) and FACT in 15 patients (88 %). The case where GT and FACT, both, missed the CST showed the highest AD and RD, whereas the one where FACT algorithm, alone, was not successfully showed the lowest AD and RD of the group. FA was reduced on the pathologic side (FApath 0.35 ± 0.16 (mean ± SD) versus FAcontralateral 0.51 ± 0.15, pcorr
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