GnRH triggering may improve euploidy and live birth rate in hyper-responders: a retrospective cohort study
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ASSISTED REPRODUCTION TECHNOLOGIES
GnRH triggering may improve euploidy and live birth rate in hyper-responders: a retrospective cohort study Justin Tan 1
&
Chen Jing 2 & Lisa Zhang 1 & Jasmine Lo 1 & Arohumam Kan 1 & Gary Nakhuda 1,2
Received: 20 October 2019 / Accepted: 22 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Despite the increasing use of GnRHa to trigger final oocyte maturation in segmented IVF cycles, the effects of trigger modality on chromosomal competence and embryo quality remain controversial. Hence, the purpose of this study was to compare euploidy rates and pregnancy outcomes among hyper-responding women using hCG versus GnRHa trigger. Methods This retrospective study included 333 hyper-responders, defined as >15 oocytes retrieved, who underwent preimplantation genetic testing (PGT-A) in segmented IVF cycles using either GnRHa or urinary hCG trigger. Live birth rate (LBR) was the primary outcome of interest. Implantation rate (IR), clinical pregnancy rate (CPR), and euploidy rate were secondary outcomes. Results GnRH triggering was associated with improved IR (70.5 vs. 53.2%, p = 0.0475), LBR (51.3 vs. 33.8%, p = 0.0170) compared to hCG. A greater number of oocytes were retrieved (21.9 vs 18.4%, p < 0.001) and euploid embryos produced (2.8 vs. 2.1, p = 0.0109) after GnRHa triggering, while higher euploidy rates were only observed among women
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