Gram-Negative Bacterial Infections and Mode of Endotoxin Actions Pat

The relevance of international symposia and congresses has been questioned with increasing frequency. All too often, presentations at such meetings are meaningful only for very few members of the audience; fundamental scientific principles and relationshi

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Bernhard Urbaschek, Renate Urbaschek, and Erwin Neter

Springer¥erlag

Wien NewYork

Gram-Negative'Bacterial Infections and Mode of Endotoxin Actions Pathophysiological, Immunological, and Clinical Aspects Immuno-Symposium, Vienna, September 1973 Sponsored by Immuno AG, Vienna

With 155 pardy colored figures Prof. Dr. Bernhard Urbasmek Dr. Renate Urbasmek Abteilung fur Immunologie und Serologie am Institut fur Hygiene und Medizinische Mikrobiologie der Fakultiit fur Klinische Medizin Mannheim der Universitiit Heidelberg Mannheim, Federal Republic of Germany

Prof. Dr. h. c. Erwin Neter, M. D. Departments of Microbiology and Pediatrics State University of New York at Buffalo Buffalo, N.Y., U.S.A.

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. © 1975 by Springer-VerlaglWien Softcover reprint of the hardcover 1st edition 1975

Library of Congress Catalogiog in Pnbllcatlon Data

Urbaschek, B

1922-

baoterial iJ:Ii'ections,and IIIOde of endotoxin actions. Includes index. 1. Bacterial diseases. 2. Gram negative bacteria. 3. Endotoxin. I. Urbaschek, R., 1936joint autho:r; II. Neter, Er:w:In, 1909joint author. III. Title. DNLM: 1. Bacterial :Infections-Immunology. 2. Ehdotoxins-Pharmaco~cs. 3. (hosm negative bacteriaPathogenicity. WG200 U72i (ho~negative

RCll5.U7

616.9'2

74-34099

ISBN-13:978-3-7091-8398-4 e-ISBN-13:978-3-7091-8396-0 DOl: 10.1007/978-3-7091-8396-0

Preface The relevance of international symposia and congresses has been questioned with increasing frequency. All too often, presentations at such meetings are meaningful only for very few members of the audience; fundamental scientific principles and relationships between disciplines are not always taken into account. Under present conditions rapid sharing of new information is highly desirable. However, many journals do not lend themselves to speedy exchange of information, nor do many provide the opportunity for the publication of discussion by various specialists of problems arising from different disciplines. Symposia may lend themselves, perhaps more readily, to the identification of current knowledge and the exchange of thoughts between scientists from various fields. It was particularly opportune to have the present symposium held in Vienna, where as early as 1365 the University was founded and where the medical sciences have played a dominant role in the investigation of the nature of diseases. It was the aim of the organizer to provide in this city the opportunity for the exchange of information and of thoughts between scientists from different disciplines and different countries. One of the many current, important problems relates to the fundamental basis of the pathogenesis of gram-negative infections. Information on immune mechanisms against these infections is inadequate; the relative role of non-specific res