Granular cell tumour of the soft tissues: a case report and literature review
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BioMed Central
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Case report
Granular cell tumour of the soft tissues: a case report and literature review NA Qureshi*, M Tahir and AR Carmichael Address: Department of General and Breast Surgery, Russells Hall Hospital, Dudley, West Midlands, UK Email: NA Qureshi* - [email protected]; M Tahir - [email protected]; AR Carmichael - [email protected] * Corresponding author
Published: 24 August 2006 International Seminars in Surgical Oncology 2006, 3:21
doi:10.1186/1477-7800-3-21
Received: 19 June 2006 Accepted: 24 August 2006
This article is available from: http://www.issoonline.com/content/3/1/21 © 2006 Qureshi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Granular cell tumours (GCT) of the soft tissues are rare benign tumours but some time may be difficult to distinguish from malignant neoplasms. It is important that clinicians are aware of their existence. We present a new case of GCT of the soft tissues followed by a brief review of literature.
Background Granular cell tumours are rare benign tumours and were first described by Weber in 1854 [1]. Abrikossoff, in his publication of 1926 [2] reported the occurrence of granular cell tumour in the tongue. He initially proposed that these tumours originate from striated muscle cells and as such referred to them as "myoblastomas." Subsequent evidence has indicated that these tumours are most likely derived from Schwann cells of the peripheral nerves [3,4]. We describe a new case of soft tissue granular cell tumour in a 47-year-old woman, with a brief review of the literature.
Case report A 47-year-old woman presented to breast clinic with a swelling over sternal region that was causing discomfort. On physical examination, there was a firm, mildly tender, 5 × 4 cm palpable lump in the midline, anterior to sternum. Overlying skin was normal and mobile. Fine needle aspiration of the lesion revealed only blood. Ultrasound guided core biopsy of the lesion showed sheets of cells with abundant granular cytoplasm and small unremarkable bland nuclei. A diagnosis of granular cell tumour was made. No evidence of malignancy was noted on the core
biopsy. The patient underwent a wide surgical excision of the tumour and had an unremarkable post-operative recovery. She was discharged the next day. The specimen submitted to pathology contained an irregular piece of soft tissue measuring 5 × 4.5 × 3 cm. The specimen weighed 27 grams. On sectioning, there was a firm nodule, which measured 2.5 cm in diameter and was whitish in colour. The nodule appeared very close to the posterior wall of the specimen. Immunohistoichemistry showed S100 to be diffusely positive, while NSE faintly positive. All these features were suggestive of granular cell tumour. Histology confirmed that excision margins
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