Green tea/isoniazid interaction
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Acute hepatitis: case report A 59-year-old man developed acute hepatitis due to concomitant administration of green tea and isoniazid. The man, who had 1-week history of general malaise and nausea, had been receiving isoniazid and pyridoxine for latent tuberculosis from past 6 weeks. Concurrently, he also received unspecified anti-TNF therapy for psoriasis. Physical examination was unrearkable. Laboratory findings revealed significant elevation of transaminases, alkaline phosphatase, GGT and bilirubin. Autoantibody and serum virology were negative. Liver ultrasound did not show structural cause for deranged liver function tests. Further he informed that he had recently started receiving green tea [green tea extract] supplementation from a local health food store. Based on the clinical picture, a diagnosis of drug-induced acute hepatitis was made, requiring hospitalisation. His acute hepatitis was likely related to concomitant administration of green tea supplementation and isoniazid. Therefore, the man’s green tea supplementation and isoniazid were stopped. Simultaneously, he received supportive therapy with IV fluids and unspecified anti-emetics. Eventually, transaminase levels reduced within days following discontinuation of green tea supplementation and isoniazid. Six weeks post presentation, his liver function normalised. He received alternative treatment with rifampicin and completed a full course without adverse events. Roche S, et al. A case of drug induced acute hepatitis resulting from isoniazid therapy with concomitant green tea extract supplementation in a patient with latent tuberculosis. American Journal of Respiratory and Critical Care Medicine 199: abstr. A5117, No. 9, 2019. Available from: URL: https://www.atsjournals.org/doi/abs/10.1164/ajrccm803446036 conference.2019.199.1_MeetingAbstracts.A5117 [abstract]
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Reactions 18 Jan 2020 No. 1787
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