Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass
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ORIGINAL CONTRIBUTIONS
Gut Microbiota Modifications and Weight Regain in Morbidly Obese Women After Roux-en-Y Gastric Bypass Silvia Leite Faria 1,2 & Andrey Santos 3 & Daniéla Oliveira Magro 4 & Everton Cazzo 4 & Heloisa Balan Assalin 3 & Dioze Guadagnini 3 & Flavio Teixeira Vieira 1 & Eliane Said Dutra 1 & Mario José Abdalla Saad 3 & Marina K. Ito 1 Received: 29 May 2020 / Revised: 1 September 2020 / Accepted: 3 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Introduction The relationship between late post-bariatric surgery weight regain and gut microbiota is not completely understood. Objective To analyze the profile of gut microbiota among patients with and without late weight regain after post-Roux-en-Y gastric bypass (RYGB) and to compare it with a control group (CG) comprised of obese Brazilian individuals. Methods This is a cross-sectional study which enrolled 34 morbidly obese women divided into 3 groups: post-Roux-en-Y gastric bypass without (RYGB_non-regain), and with weight regain (RYGB_regain) at least 5 years after surgery, and a CG of preoperative individuals. Gut microbiota was determined by metagenomic analyses. Results The alpha diversity was higher in groups RYGB non-regain and RYGB regain when compared with CG (p < 0.05). Both RYGB non-regain and RYGB regain groups showed a lower abundance of the phylum Bacteroidetes when compared with CG (p < 0.01). The genera Bacteroides and SMB53 were increased in CG (p < 0.05). Group RYGB non-regain showed more abundance of the Akkermansia genus when compared with CG and group RYGB regain (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and lower of the SMB53 genus when compared with CG (p < 0.05). RYGB non-regain showed a greater abundance of the Phascolarctobacterium genus and a lower of the SMB53 genus when compared with CG (p < 0.05). Conclusion The gut microbiota of individuals which presented late weight regain after RYGB was significantly different in comparison to individuals with a successful weight loss, a finding that points towards a significant role of gut microbiota on weight loss and maintenance after surgery. Keywords Obesity . Gastric bypass . Weight loss . Microbiota . Bariatric surgery
Silvia Leite Faria and Andrey Santos contributed equally to this work. * Andrey Santos [email protected]
Eliane Said Dutra [email protected] Mario José Abdalla Saad [email protected]
Silvia Leite Faria [email protected]
Marina K. Ito [email protected]
Daniéla Oliveira Magro [email protected] Everton Cazzo [email protected] Heloisa Balan Assalin [email protected]
1
Departament of Human Nutrition, University of Brasilia, Brasilia, DF, Brazil
2
Gastrocirurgia de Brasilia, Brasilia, DF, Brazil
3
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Rua Tessália Vieira de Camargo, 126 Cidade Universitária Zeferino Vaz, Campinas, SP 13084-971, Brazil
4
Department of Surgery, Facul
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