Hair Selenium Content in Middle-Aged and Elderly Chinese Population
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Hair Selenium Content in Middle-Aged and Elderly Chinese Population Mengli Li 1 & Hang Yun 1 & Jie Huang 2 & Jian Wang 2 & Wansheng Wu 2 & Remmei Guo 2 & Li Wang 1 Received: 17 July 2020 / Accepted: 8 November 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Selenium (Se) is an essential nutrient element for human health, and middle-aged and elderly people (age ≥ 45 years old) are at higher risk of nutrient deficiency including Se due to their physiological characteristics. This study investigated the hair Se content of middle-aged and elderly people in China with the purpose of providing a reference for prescription of hair Se normal range in this population. In this study, the hair Se content of 2155 middle-aged and elderly people was detected with atomic fluorescence photometry. The participants were recruited from 15 provinces or municipalities spreading from south to north of China with a diverse Se content in soil. Additionally, the relationships between hair Se content with sex, age, and BMI were analyzed. The results found that the median and 95% quantile of hair Se content were 0.36 μg/g and 0.60 μg/g respectively, with a range of 0.08 to 20.04 μg/g in middle-aged and elderly Chinese. The hair Se content mostly concentrated at 0.23~0.48 μg/g in 81.11% of participants. The participants in Guangdong and Hunan provinces had the highest hair Se levels (medians were 0.51 and 0.50 μg/g, respectively), while Henan and Shaanxi provinces had the lowest levels (medians were 0.30 and 0.29 μg/g, respectively). In addition, the Se content of males was higher than that of females (p < 0.05), whereas there was no significant difference between different ages and BMI (p > 0.05). In conclusion, this study found that the hair Se content of middle-aged and elderly Chinese ranges from 0.08 to 20.04 μg/g, with median and 95% quantile of 0.36 μg/g and 0.60 μg/g, respectively. Our results provide a reference for the establishment of hair Se content in this population and suggest that the differences of region and sex should be considered when setting up the range. Keywords Chinese . Middle-aged and elderly . Hair selenium . Sex
Introduction Selenium (Se) is one of the essential micronutrients involved in human energy metabolism and gene expression [1]. It is the composition of 25 proteins including glutathione peroxide reductase and oxygen–sulfur reductase and Mengli Li and Hang Yun contributed equally to this work. * Li Wang [email protected] Mengli Li [email protected] Hang Yun [email protected] 1
School of Nursing, Medical College, Soochow University, No.1 Shizi Street, Suzhou 215006, China
2
Research Center, Soochow Setek Biotechnology Co., Ltd., Suzhou 215123, China
has important biological functions such as anti-oxidation, anti-aging, immune regulation, and protection of cell structure and function [2, 3]. Insufficient intake of Se will elevate the body’s oxidative stress and reduce immunity [4], causing many endemic diseases such as Keshan disease (KSD), Kashin–Beck d
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